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BACKGROUND AND PURPOSE The aim of this study was to identify the mechanism underlying the auditory discriminatory process reflected in mismatch negativity (MMN), using time-frequency analysis of single-trial event-related potentials (ERPs). METHODS Two auditory tones of different probabilities (oddball paradigm) and the same probability (control paradigm)(More)
BACKGROUND Restless legs syndrome (RLS) is a sensorimotor neurological disorder characterized by an irresistible urge to move the legs. It has been reported that RLS patients show cognitive deficits, presumably due to hyperactivity causing loss of attention, or malfunctions in the frontal region resulting from sleep deprivation. However, the mechanism(More)
BACKGROUNDS It has been reported that patients with restless legs syndrome (RLS) may have cognitive deficit. The authors performed EEG and ERP analysis during daytime to identify electrophysiologic relations with cognitive dysfunction in unmedicated RLS patients. METHODS Seventeen drug naive RLS patients (53.7±9.6 years) and 13 age-matched healthy(More)
Mismatch negativity (MMN) is a negative component of event-related potential (ERP) that reflects auditory deviant detection. Previous studies repeatedly suggested that MMN is generated by the fronto-temporal network. However, it is still unclear how the frontal and temporal areas interact. To verify this, we observed the spatiotemporal pattern of(More)
BACKGROUND AND PURPOSE Neuropsychological and neuroimaging studies both suggest that frontal lobe dysfunction is present in migraineurs. Since P3a abnormalities manifest in other diseases associated with attention problems, such as attention deficit hyperactivity disorder, we hypothesized that migraine patients have P3a abnormalities, particularly in the(More)
BACKGROUND AND PURPOSE Periodic limb movements (PLM) during sleep (PLMS) are associated with cortical and cardiovascular activation. Changes in cerebral hemodynamics caused by cortical activity can be measured using near-infrared spectroscopy (NIRS). We investigated oscillatory components of cerebral hemodynamics during PLM and different sleep stages in(More)
OBJECTIVES We aimed to describe the sensory topography of restless legs syndrome (RLS) sensory symptoms and to identify the relationship between topography and clinical variables. METHODS Eighty adult patients with drug-naïve RLS who had symptoms for more than 1year were consecutively recruited. During face-to-face interviews using a structured paper and(More)
Recent event-related potential (ERP) and functional magnetic resonance imaging (fMRI) studies suggest that novelty processing may be involved in processes that recognize the meaning of a novel sound, during which widespread cortical regions including the right prefrontal cortex are engaged. However, it remains unclear how those cortical regions are(More)
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