Guzel Valeeva

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Severe head trauma causes widespread neuronal shear injuries and acute seizures. Shearing of neural processes might contribute to seizures by disrupting the transmembrane ion gradients that subserve normal synaptic signaling. To test this possibility, we investigated changes in intracellular chloride concentration ([Cl(-)](i)) associated with the widespread(More)
Gamma oscillations have long been considered to emerge late in development. However, recent studies have revealed that gamma oscillations are transiently expressed in the rat barrel cortex during the first postnatal week, a "critical" period of sensory-dependent barrel map formation. The mechanisms underlying the generation and physiological roles of early(More)
In the developing hippocampus, GABA exerts depolarizing and excitatory actions and contributes to the generation of neuronal network driven giant depolarizing potentials (GDPs). Here, we studied spike time coding at immature GABAergic synapses and its impact on synchronization of the neuronal network during GDPs in the neonatal (postnatal days P2-6) rat(More)
The series of atlases of the developing rat brain in stereotaxic coordinates that we propose here1,2 has been conceived as a tool for the exploration of the rat brain in vivo during the postnatal period, offering a choice of bregma and lambda as the reference points. We suggest to use this atlas, which provides stereotaxic coordinates, in combination with(More)
Inhibition of serotonin uptake, which causes an increase in extracellular serotonin levels, disrupts the development of thalamocortical barrel maps in neonatal rodents. Previous in vitro studies have suggested that the disruptive effect of excessive serotonin on barrel map formation involves a depression at thalamocortical synapses. However, the effects of(More)
The excitatory action of gamma-aminobutyric acid (GABA) is considered to be a hallmark of the developing nervous system. However, in immature brain slices, excitatory GABA actions may be secondary to neuronal injury during slice preparation. Here, we explored GABA actions in the rodent intact hippocampal preparations and at different depths of hippocampal(More)
Characteristics of spermatogenesis, morphometric changes in the Leydig's and Sertoli's cells, and fertility of albino rats exposed to various doses of 2.4-D were investigated. Chronic injection of the herbicide led to transitional sterility against pronounced disorders of spermatogenesis, hyperplasia of sertolicytes and predominance of low-active forms of(More)
Early in development, GABA, which is the main inhibitory neurotransmitter in adult brain, depolarizes immature neurons and exerts dual--excitatory and shunting/inhibitory--effects in the developing neuronal networks. The present review discusses some general questions, including the properties of excitation at depolarizing GABAergic synapse and shunting(More)
We present a novel non-invasive technique to measure the polarity of GABAergic responses based on cell-attached recordings of currents activated by laser-uncaging of GABA. For these recordings, a patch pipette was filled with a solution containing RuBi-GABA, and GABA was released from this complex by a laser beam conducted to the tip of the patch pipette(More)
During development, sensory systems switch from an immature to an adult mode of function along with the emergence of the active cortical states. Here, we used patch-clamp recordings from neocortical slices in vitro to characterize the developmental changes in the basic electrophysiological properties of excitatory L4 neurons and their connectivity before(More)