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Background A large calcium-insensitive transient outward current (Ito) has been recorded in atria, left ventricular (LV) free wall, and right ventricular septal subendocardium of the human heart.… (More)
Hypertrophied and failing cardiac myocytes generally show alterations in intracellular Ca2+ handling associated with changes in the contractile function and arrhythmogenicity. The cardiac Na+-Ca2+… (More)
Abstract The Cl−-HCO3− exchanger is the main anionic exchanger (AE) that alleviates alkaline loads in cardiac cells. We recently identified in adult ventricular cells two membrane proteins (80 and… (More)
Abstract—Aldosterone is associated with the pathogenesis and progression of left ventricular hypertrophy and heart failure, independent of its relation with arterial blood pressure. However, little… (More)
Abstract ATP-sensitive K+ (KATP) channels are present at high density in membranes of cardiac cells, where they regulate cardiac function during metabolic impairment. The present study analyzes the… (More)