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BACKGROUND Bacterial vaginosis (BV), which is highly prevalent in the African population, is one of the most common vaginal syndromes affecting women in their reproductive age placing them at increased risk for sexually transmitted diseases including infection by human immunodeficiency virus-1. The vaginal microbiota of a healthy woman is often dominated by(More)
Authors • Controversy around best time to initiate antiretroviral therapy (ART) • CIPRA Haiti showed delayed disease progression and increased survival at CD4 cell counts 250-350 compared to <200 CD4 cell count • At higher CD4, observational studies from developed countries suggested a benefit from earlier initiation of ART – Benefit relative to toxicity(More)
Role of Contributors The core protocol team (CC, AW, JRL, JMB, LC, AM, JPH) designed the study and JPH and KT performed the primary data analysis. All investigators were involved in data collection, reviewed manuscript drafts and approved the final manuscript; JRL, JMB and CC wrote the initial manuscript draft and vouch for the data, analysis, and(More)
OBJECTIVE We evaluated genetic variants in 51 candidate genes encoding proteins that interact with HIV-1 during the virus life cycle for association with HIV-1 outcomes in an African cohort. METHODS Using a nested case-control study within a cohort of heterosexual HIV-1-serodiscordant couples, we genotyped 475 haplotype-tagging single-nucleotide(More)
BACKGROUND We conducted a review of the diagnostic accuracy of clinical examination for the diagnosis of cirrhosis. The objectives were: to identify studies assessing the accuracy of clinical examination in the detection of cirrhosis; to summarize the diagnostic accuracy of reported physical examination findings; and to define the effects of study(More)
The generation of polyfunctional CD8+ T cells, in response to vaccination or natural infection, has been associated with improved protective immunity. However, it is unclear whether the maintenance of polyfunctionality is related to particular cellular phenotypic characteristics. To determine whether the cytokine expression profile is linked to the memory(More)
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