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Roundabout Controls Axon Crossing of the CNS Midline and Defines a Novel Subfamily of Evolutionarily Conserved Guidance Receptors

• Thomas Kidd, Katja Brose, +4 authors Guy Tear
• Cell
• 1998

The robo gene in Drosophila was identified in a large-scale mutant screen for genes that control the decision by axons to cross the CNS midline. In robo mutants, too many axons cross and recross the… (More)

Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline.

• Matthew W. Seeger, Guy Tear, Dolores Ferres-Marco, Charlie Goodman
• Neuron
• 1993

We performed a large-scale screen for mutations that affect the development of CNS axon pathways in the Drosophila embryo. We screened embryos from over 13,500 balanced lines and saved over 250… (More)

Dosage-Sensitive and Complementary Functions of Roundabout and Commissureless Control Axon Crossing of the CNS Midline

• Thomas Kidd, Claire Russell, Corey S. Goodman, Guy Tear
• Neuron
• 1998

commissureless and roundabout lead to complementary mutant phenotypes in which either too few or too many axons cross the midline. The robo;comm double-mutant phenotype is identical to robo alone,… (More)

glial cells missing: a genetic switch that controls glial versus neuronal fate

• Bradley Jones, Richard Fetter, Guy Tear, Corey S. Goodman
• Cell
• 1995

The glial cells missing (gcm) gene in Drosophila encodes a novel nuclear protein that is transiently expressed early in the development of nearly all glia. In loss-of-function gcm mutant alleles,… (More)

commissureless Controls Growth Cone Guidance across the CNS Midline in Drosophila and Encodes a Novel Membrane Protein

• Guy Tear, Robin C Harris, Saum Sutaria, Krystyna Kilomanski, Corey S. Goodman, Mark A. Seeger
• Neuron
• 1996

The commissureless (comm) gene was identified previously in a large-scale screen for mutations that disrupt CNS axon pathways in Drosophila. The comm gene has a unique mutant phenotype: the complete… (More)

Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells.

• Martin Büscher, Shin Yeo, +4 authors Wan Ni Chia
• Genes & development
• 1998

Asymmetric cell division is a widespread mechanism in developing tissues that leads to the generation of cell diversity. In the embryonic central nervous system of Drosophila melanogaster, secondary… (More)

The extracellular Leucine-Rich Repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns

• Jackie Dolan, Karen Walshe, +6 authors Kevin J. Mitchell
• BMC Genomics
• 2007

Leucine-rich repeats (LRRs) are highly versatile and evolvable protein-ligand interaction motifs found in a large number of proteins with diverse functions, including innate immunity and nervous… (More)

Interactions between the juvenile Batten disease gene, CLN3, and the Notch and JNK signalling pathways

• Richard I. Tuxworth, Valérie Vivancos, Megan B. O'Hare, Guy Tear
• Human molecular genetics
• 2009

Mutations in the gene CLN3 are responsible for the neurodegenerative disorder juvenile neuronal ceroid lipofuscinosis or Batten disease. CLN3 encodes a multi-spanning and hydrophobic transmembrane… (More)

Drosophila Nedd4, a Ubiquitin Ligase, Is Recruited by Commissureless to Control Cell Surface Levels of the Roundabout Receptor

• Anna M. Myat, Pauline C Henry, Veronica McCabe, Louisa Flintoft, Daniela Rotin, Guy Tear
• Neuron
• 2002

Crossing the midline produces changes in axons such that they are no longer attracted to the midline. In Drosophila, Roundabout reaches high levels on axons once they have crossed the midline, and… (More)

Use of model organisms for the study of neuronal ceroid lipofuscinosis.

• Michael Bond, Sophia-Martha kleine Holthaus, Imke Tammen, Guy Tear, Claire Russell
• Biochimica et biophysica acta
• 2013

Neuronal ceroid lipofuscinoses are a group of fatal progressive neurodegenerative diseases predominantly affecting children. Identification of mutations that cause neuronal ceroid lipofuscinosis, and… (More)

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