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Members of the SOX family of transcription factors are found throughout the animal kingdom, are characterized by the presence of a DNA-binding HMG domain, and are involved in a diverse range of developmental processes. Previous attempts to group SOX genes and deduce their structural, functional, and evolutionary relationships have relied largely on complete(More)
Results are presented for a measurement for the production of the anti-hydrogen atom H 0 pe + , the simplest atomic bound state of antimatter. A method has been used by the PS210 collaboration at LEAR which assumes that the production of H 0 is predominantly mediated by the e + e ? { pair creation via the two{photon mechanism in the antiproton{nucleus(More)
Satiated pigeons received intracerebroventricular injections of either ostrich (0.06, 0.3 and 1.5 nmoles) or human (0.06 and 1.5 nmoles) beta-endorphin, or a control solution, and their consumption of food and water was monitored during the half hour after these treatments. At each administered dose, ostrich beta-endorphin enhanced food without altering(More)
Positrons are used to cool antiprotons for the first time. The oppositely charged positrons and antiprotons are first simultaneously accumulated in separate Penning trap volumes, and then are spatially merged in a nested Penning trap. The antiprotons cool until they reach a low relative velocity with respect to the cold positrons, the situation expected to(More)
The PANDA Experiment aimes for high quality hadron spec-troscopy using the antiproton source of the FAIR facility planned at GSI. Situated in the barrel section of the fixed target experiment the DIRC (Detection of Internally Reflected Cherenkov photons) detector provides a positive kaon identification and serves for the destinction of gammas and(More)
The synthesis, base-pairing properties and in vitro and in vivo characteristics of 5-methyl-isocytosine (isoC(Me) ) and isoguanine (isoG) nucleosides, incorporated in an HNA(h) (hexitol nucleic acid)-DNA(d) mosaic backbone, are described. The required h-isoG phosphoramidite was prepared by a selective deamination as a key step. As demonstrated by Tm(More)
A series of 3′-O-methylated-d-altrohexitol nucleoside analogs (MANA) was synthesized comprising all four base moieties, adenine, cytosine, uracil, and guanine. These monomers were incorporated into oligonucleotides (ONs) by automated solid phase synthesis and the thermal and thermodynamic stability of all new modified constructs were evaluated. Data were(More)
One of the PID-subdetectors of PANDA is a DIRC detector. With a DIRC (Detection of Internally Reflected Cherenkov photons) detector the velocity of relativistic charged particles will be measured via the determination of the angle of the Cherenkov cone. The installation of a test setup for the radiator materials and first results are reported. Tests with(More)
In further study of our series of six-membered ring-containing nucleic acids, different 1',3'-di-O-methyl altropyranoside nucleoside analogs (DMANA) were synthesized comprising all four base moieties, adenine, cytosine, uracil and guanine. Following assembly into oligonucleotides (ONs), their affinity for natural oligonucleotides was evaluated by thermal(More)
The PANDA experiment at the facility for anti-proton and ion research (FAIR) will study the strong interaction by precision spectroscopy. A detector system with excellent particle identification (PID) is therefore required. Charged hadron identification in the barrel region will be performed by ka compact ring imaging Cherenkov detector based on the DIRC(More)