Guy S. Bewick

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Optical analysis of synaptic vesicle recycling at the frog neuromuscular junction.

The fluorescent dyes FM1-43 and RH414 label motor nerve terminals in an activity-dependent fashion that involves dye uptake by synaptic vesicles that are recycling. This allows optical monitoring of… (More)

Activity-dependent fluorescent staining and destaining of living vertebrate motor nerve terminals.

William J. Betz, Feng Mao, Guy S. Bewick
The Journal of neuroscience : the official…
1992

Living motor nerve terminals from several species can be stained in an activity-dependent fashion by certain styryl dyes, such as RH414, RH795, and a new dye, FM1-43, which can be imaged… (More)

Autogenic modulation of mechanoreceptor excitability by glutamate release from synaptic-like vesicles: evidence from the rat muscle spindle primary sensory ending.

Guy S. Bewick, Brian Reid, Christine Richardson, Robert W Banks
The Journal of physiology
2005

Fifty-nanometre diameter, clear, synaptic-like vesicles (SLVs) are found in primary mechanosensory nerve terminals of vertebrate and invertebrate animals. We have investigated their role in… (More)

Optical monitoring of transmitter release and synaptic vesicle recycling at the frog neuromuscular junction.

William J. Betz, Guy S. Bewick
The Journal of physiology
1993

1. Frog cutaneous pectoris motor nerve terminals were loaded with the fluorescent dye FM1-43, which produced a series of discrete spots along the length of terminals, each spot evidently marking a… (More)

Synaptic vesicle dynamics in rat fast and slow motor nerve terminals.

Brian Reid, Clarke R. Slater, Guy S. Bewick
The Journal of neuroscience : the official…
1999

We have investigated whether rat motor nerve terminals with different in vivo activity patterns also have different vesicle trafficking characteristics. To do this, we monitored, using combined… (More)

Different distributions of dystrophin and related proteins at nerve-muscle junctions.

Guy S. Bewick, Louise V. B. Nicholson, Carol Young, Elaine O'Donnell, Clarke R. Slater
Neuroreport
1992

The distributions of dystrophin, 'dystrophin-related protein' (DRP) and beta-spectrin were compared with that of acetylcholine receptors (AChRs) at rat nerve-muscle junctions (NMJs) using… (More)

Intracellular movements of fluorescently labeled synaptic vesicles in frog motor nerve terminals during nerve stimulation

William J. Betz, Guy S. Bewick, R. M. A. P. Ridge
Neuron
1992

We stained synaptic vesicles in frog motor nerve terminals with FM1-43 and studied changes in the shape and position of vesicle clusters during nerve stimulation. Each stained vesicle cluster… (More)

Mechanotransduction in the muscle spindle

Guy S. Bewick, Robert W Banks
Pflügers Archiv - European Journal of Physiology
2014

The focus of this review is on the principal sensory ending of the mammalian muscle spindle, known as the primary ending. The process of mechanosensory transduction in the primary ending is examined… (More)

Functional expression of cell surface cannabinoid CB(1) receptors on presynaptic inhibitory terminals in cultured rat hippocampal neurons.

Andrew J. Irving, Angela A. Coutts, +4 authors Roger G Pertwee
Neuroscience
2000

At present, little is known about the mechanisms by which cannabinoids exert their effects on the central nervous system. In this study, fluorescence imaging and electrophysiological techniques were… (More)

Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles.

Anna Simon, Fiona C. Shenton, Irene Hunter, Robert W Banks, Guy S. Bewick
The Journal of physiology
2010

We investigated whether channels of the epithelial sodium/amiloride-sensitive degenerin (ENaC/DEG) family are a major contributor to mechanosensory transduction in primary mechanosensory afferents,… (More)

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