Guy R. Lambert

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The binary, ternary, quaternary, and quintary interactions of a five-component mixture of carcinogenic environmental polycyclic aromatic hydrocarbons (PAHs) using response surface analyses are described. Initially, lung tumor dose-response curves in strain A/J mice for each of the individual PAHs benzo[a]pyrene (B[a]P), benzo[b]fluoranthene (B[b]F),(More)
We have studied adduct formation of the antineoplastic agent diazi-quone (AZQ; NSC 182986) with DNA and nucleotides in vitro. The a/iridine moieties of AZQ can be expected to interact covalently with DNA which, in turn, presumably elicits the antitumor activity. We analyzed AZQ-DNA adducts by a modified "P-postlabeling assay in volving purification of the(More)
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