Guy Martin

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In late 2008, DISA (Defense Information Systems Agency), the global IT arm of the US Department of Defense, embarked upon a project to create an internal collaboration and software application lifecycle management system. Beyond simply fielding yet another tool, the Forge.mil effort was designed to fundamentally change the way the DoD developed and acquired(More)
Sodium valproate is a drug widely used for the treatment of epilepsy and mood disorders. We studied the effect of valproate on cerebral energy metabolism by incubating rat brain slices with 5 mM [3-(13)C]glutamate in the absence and the presence of 1 mM valproate. Substrate removal and product formation were measured by enzymatic and carbon 13 NMR methods.(More)
This study was performed to analyze the metabolic fate of a high concentration (5 mM) of glutamine and glutamate in rat brain slices and the participation of these amino acids in the glutamine-glutamate cycle. For this, brain slices were incubated for 60 min with [3-¹³C]glutamine or [3-¹³C]glutamate. Tissue plus medium extracts were analyzed by enzymatic(More)
  • Gregory J. Hobbs, Carly Hernandez, Douglas Kenney, Shaun LaBarre, Amelia Peterson, Matt Samelson +18 others
  • 2015
For more than a half century, Colorado Law's natural resources law program has led the nation. And for most of that period, this leadership has been housed in the Getches—Wilkinson Center for Natural Resources, Energy and the Environment (formerly known as the Natural Resources Law Center). In order to continue and strengthen the legacy of the Center, Dean(More)
In late 2008, DISA (Defense Information Systems Agency), the global IT arm of the US Department of Defense, embarked upon a project to create an internal collaboration and software application lifecycle management system. Beyond simply fielding yet another tool, the Forge.mil effort was designed to fundamentally change the way the DoD developed and acquired(More)
  • Tony Karbo, Guest Editor, Catherine Nelson, Benjamin Broome, Jean-Bosco Butera, Kevin Clements +12 others
  • 2011
The mission of the University for Peace is to provide humanity with an international institution of higher education for peace with the aim of promoting among all human beings a spirit of understanding, tolerance , and peaceful coexistence, to stimulate cooperation among peoples, and to help lessen obstacles and threats to world peace and progress in(More)
Since glucose is the main cerebral substrate, we have characterized the metabolism of various (13)C glucose isotopomers in rat brain slices. For this, we have used our cellular metabolomic approach that combines enzymatic and carbon 13 NMR techniques with mathematical models of metabolic pathways. We identified the fate and the pathways of the conversion of(More)
Continuous cultures of Hansenula anomala were carried out in media at low water activity, resulting from NaCl addition. Three dilution rates were compared and it was shown that a clear steady state was only recorded for the lowest dilution rate tested (0.03 h−1), leading to a biomass concentration of 4.3 g L−1. At 0.06 h−1 dilution rate, steady state was(More)
The effect of an osmotic stress resulting from high glucose or NaCl concentrations on the morphology and intracellular volume of Hansenula anomala was examined by scanning electronic microscopy and changes in the intracellular volume accessible to tritiated water, respectively. No noticeable change in the cell morphology was observed, with the cells(More)