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In late 2008, DISA (Defense Information Systems Agency), the global IT arm of the US Department of Defense, embarked upon a project to create an internal collaboration and software application lifecycle management system. Beyond simply fielding yet another tool, the Forge.mil effort was designed to fundamentally change the way the DoD developed and acquired(More)
Since glucose is the main cerebral substrate, we have characterized the metabolism of various (13)C glucose isotopomers in rat brain slices. For this, we have used our cellular metabolomic approach that combines enzymatic and carbon 13 NMR techniques with mathematical models of metabolic pathways. We identified the fate and the pathways of the conversion of(More)
Sodium valproate is a drug widely used for the treatment of epilepsy and mood disorders. We studied the effect of valproate on cerebral energy metabolism by incubating rat brain slices with 5 mM [3-(13)C]glutamate in the absence and the presence of 1 mM valproate. Substrate removal and product formation were measured by enzymatic and carbon 13 NMR methods.(More)
The expression of members of the Fos and Jun families is examined by immunohistochemistry in the brains of two patients with multiple sclerosis (MS). Strong c-Jun immunoreactivity is observed in the cytoplasm of neurons located in the vicinity of subacute plaques, but not in neurons of brain compartments not compromised by MS and in the neighborhood of(More)
1. Extracellular K+ activity in frog ventricular muscle was monitored with a K+-selective micro-electrode during and following periods of rapid stimulation. 2. During activity K+ accumulated in the paracellular space, declined with continued beating and became depleted below bathing K+ concentrations, [K+], when activity was terminated. 3. The re-uptake and(More)
This study was performed to analyze the metabolic fate of a high concentration (5 mM) of glutamine and glutamate in rat brain slices and the participation of these amino acids in the glutamine-glutamate cycle. For this, brain slices were incubated for 60 min with [3-¹³C]glutamine or [3-¹³C]glutamate. Tissue plus medium extracts were analyzed by enzymatic(More)
In late 2008, DISA (Defense Information Systems Agency), the global IT arm of the US Department of Defense, embarked upon a project to create an internal collaboration and software application lifecycle management system. Beyond simply fielding yet another tool, the Forge.mil effort was designed to fundamentally change the way the DoD developed and acquired(More)
  • Guy Martin
  • 2015
The tilted assumption, a remnant of analog cameras, is still in use. It seeks to compensate the off squareness of the image plane with the lens axis, but in fact creates a systematic shape alteration by introducing a scale variation in the image, and adds shear with the use of a skew parameter. It results in an image center bias which in turn offsets every(More)
For more than a half century, Colorado Law's natural resources law program has led the nation. And for most of that period, this leadership has been housed in the Getches—Wilkinson Center for Natural Resources, Energy and the Environment (formerly known as the Natural Resources Law Center). In order to continue and strengthen the legacy of the Center, Dean(More)