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A recurrent malignant glioma was treated with cisplatin delivered directly into the tumor. The drug was delivered via 68 small catheters distributed evenly throughout the tumor area. Each catheter was connected to an osmotic minipump that delivered 0.5 microliter of drug solution each hour for 10 days. There were no side effects from the catheter(More)
Plasticity at the cerebellar parallel fiber to Purkinje cell synapse may underlie information processing and motor learning. In vivo, parallel fibers appear to fire in short high frequency bursts likely to activate sparsely distributed synapses over the Purkinje cell dendritic tree. Here, we report that short parallel fiber tetanic stimulation evokes a(More)
In 131 patients treated exclusively by selective denervation during the past 10 years, all or almost all the abnormal movements of spasmodic torticollis were suppressed in 115 (88%) while preserving posture and mobility. This approach was also used in certain forms of adult-onset dystonia. An appreciable amount of abnormal movements remained in the other(More)
OBJECTIVE The incidence and severity of venous air embolism (VAE), a potentially fatal complication, among patients undergoing selective peripheral denervation in the sitting position have never been clearly established. We designed this retrospective study to assess the incidence and severity of VAE, the incidence of paradoxical air embolism, and the(More)
Chronic depth electrode recording has proven to be a safe and indispensable tool for the investigation of intractable seizures. Anterior callosotomy appears as an excellent palliative treatment at least in bifrontal foci. It is hoped that chronic depth electrode recording will be used more widely before callosotomy in order to establish more clearly the(More)
There is a continuous search for more efficient treatment of malignant cerebral gliomas. The work of Penn and Croin demonstrates clearly that survival of rats having experimental gliomas is significantly increased by intratumoral chemotherapy. It has been shown that chronic depth electrodes for the investigation of epileptic patients is a reliable and safe(More)
We studied 24 patients who had adversion as the first clinical manifestation of seizures. Seizures were recorded with depth electrodes as part of the evaluation for possible surgery for epilepsy. Head rotation did not help to lateralize the epileptic focus clinically, because deviations occurred ipsilaterally to the EEG focus in some patients, and because(More)