Gustavo Rodrigues Martins

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Mammary neoplasias are the most common tumors observed in female dogs. Identification of these tumors is valuable in order to identify beneficial therapeutic agents as alternative treatments for this tumor type. Oral administration of melatonin appears to exert an oncostatic effect on mammary neoplasia and may have a possible mechanism of action through its(More)
Background Once a tumor lesion exceeds a few millimeters in diameter, hypoxia triggers a cascade of events to allow angiogenesis and tumor progression. As angiogenesis is essential for tumor growth and metastasis, controlling tumor-associated angiogenesis is a promising tactic in limiting cancer progression. Melatonin has been suggested to inhibit(More)
Inflammation results in the production of cytokines, such as interleukin- (IL-) 4 and IL-10 with immunosuppressive properties or IL-6 and TNF-α with procarcinogenic activity. Furthermore, NF-κB is the major link between inflammation and tumorigenesis. This study verified the interaction between active inflammatory cytokines in the tumor microenvironment and(More)
Background Angiogenesis plays an important role in the pathogenesis of several malignancies, including breast cancer. Tumor growth requires the formation of new blood vessels that are stimulated by angiogenic factors, which initiates the sprouting and proliferation of endothelial cells. Curcumin is used as food and in traditional medicine, however evidences(More)
Background Due to the many similarities shared by humans and dogs, canine mammary tumors are an excellent model to comprehend various aspects of mammary neoplasias. The tumor cells have the ability to promote changes in their functionality in order to survive. In situations of hypoxia, tumor cells produce and release pro and antiangiogenic factors that(More)
Mammary tumors are the most common type of tumor in dogs, with approximately half of these tumors being malignant. Hypoxia, characterized by oxygen levels below normal, is a known adverse factor to cancer treatment. The hypoxia-inducible factor 1α (HIF-1α) is a central regulator of the pathophysiological response of mammalian cells to low oxygen levels.(More)
Background Mammary tumors of dogs are an excellent model to investigate the clinical and pathological diagnosis and prognosis of cancer. Interleukins play a key role in cancer, particularly interleukin-8, which has tumorigenic and pro-angiogenic properties and interleukin-12, with anti-metastatic and angiogenic properties. The carbohydrate antigen tumor(More)
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