Gustavo F. Bayón

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In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in repressive histone post-translational modifications. However, the chromatin marks associated with changes in DNA methylation in adult stem cells during lifetime are still largely unknown. Here, DNA methylation profiling of mesenchymal stem cells (MSCs) obtained(More)
Learning preferences is a useful tool in application fields like information retrieval, or system configuration. In this paper we show a new application of this Machine Learning tool, the analysis of sensory data provided by consumer panels. These data sets collect the ratings given by a set of consumers to the quality or the acceptability of market(More)
Maternal smoking during pregnancy is a major risk factor for adverse health outcomes. The main objective of the study was to assess the impact of in utero tobacco exposure on DNA methylation in children born at term with appropriate weight at birth. Twenty mother-newborn dyads, after uncomplicated pregnancies, in the absence of perinatal illness were(More)
OBJECTIVE The purpose of this study was to determine the global patterns of aberrant DNA methylation in thyroid cancer. RESEARCH DESIGN AND METHODS We have used DNA methylation arrays to determine, for the first time, the genome-wide promoter methylation status of papillary, follicular, medullary, and anaplastic thyroid tumors. RESULTS We identified 262(More)
In this paper we tackle a real world problem, the search of a function to evaluate the merits of beef cattle as meat producers. The independent variables represent a set of live animals' measurements; while the outputs cannot be captured with a single number, since the available experts tend to assess each animal in a relative way, comparing animals with(More)
In this paper we show that it is possible to model sensory impressions of consumers about beef meat. This is not a straightforward task; the reason is that when we are aiming to induce a function that maps object descriptions into ratings, we must consider that consumers’ ratings are just a way to express their preferences about the products presented in(More)
The quality of food can be assessed from different points of view. In this paper, we deal with those aspects that can be appreciated through sensory impressions. When we are aiming to induce a function that maps object descriptions into ratings, we must consider that consumers’ ratings are just a way to express their preferences about the products presented(More)
STUDY QUESTION Are there DNA methylation alterations in sperm that could explain the reduced biological fertility of male partners from couples with unexplained infertility? SUMMARY ANSWER DNA methylation patterns, not only at specific loci but also at Alu Yb8 repetitive sequences, are altered in infertile individuals compared with fertile controls. (More)
Early life epigenetic programming influences adult health outcomes. Moreover, DNA methylation levels have been found to change more rapidly during the first years of life. Our aim was the identification and characterization of the CpG sites that are modified with time during the first years of life. We hypothesize that these DNA methylation changes would(More)
The liver X receptor agonist, GW3965, improves cognition in Alzheimer’s disease (AD) mouse models. Here, we determined if short-term GW3965 treatment induces changes in the DNA methylation state of the hippocampus, which are associated with cognitive improvement. Twenty-four-month-old triple-transgenic AD (3xTg-AD) mice were treated with GW3965 (50(More)