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Intramyocardial delivery of CD133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and efficacy studies.

• Christof Stamm, H. -D. Kleine, +9 authors Gustav Steinhoff
• The Journal of thoracic and cardiovascular…
• 2007

OBJECTIVES Cell therapy may offer novel therapeutic options for chronic ischemic heart disease. In a clinical trial, we first assessed the feasibility and safety of intramyocardial CD133+ bone marrow… (More)

Autologous bone-marrow stem-cell transplantation for myocardial regeneration

• Christof Stamm, Bernd Westphal, +7 authors Gustav Steinhoff
• The Lancet
• 2003

Implantation of bone-marrow stem cells in the heart might be a new method to restore tissue viability after myocardial infarction. We injected up to 1.5x10(6) autologous AC133+ bone-marrow cells into… (More)

Bcl-2 engineered MSCs inhibited apoptosis and improved heart function.

• Wenzhong Li, Nan Ma, +11 authors Gustav Steinhoff
• Stem cells
• 2007

Engraftment of mesenchymal stem cells (MSCs) derived from adult bone marrow has been proposed as a potential therapeutic approach for postinfarction left ventricular dysfunction. However, limited… (More)

Tissue engineering of pulmonary heart valves on allogenic acellular matrix conduits: in vivo restoration of valve tissue.

• Gustav Steinhoff, Ulrich A. Stock, +6 authors Augustinus Bader
• Circulation
• 2000

BACKGROUND Tissue engineering using in vitro-cultivated autologous vascular wall cells is a new approach to biological heart valve replacement. In the present study, we analyzed a new concept to… (More)

Tissue engineering of heart valves--human endothelial cell seeding of detergent acellularized porcine valves.

• Augustinus Bader, Tobias Schilling, +4 authors Axel Haverich
• European journal of cardio-thoracic surgery…
• 1998

OBJECTIVE Tissue engineering of heart valves represents a new experimental concept to improve current modes of therapy in valvular heart disease. Drawbacks of glutaraldehyde fixed tissue valves or… (More)

Granulocyte colony-stimulating factor exacerbates cardiac fibrosis after myocardial infarction in a rat model of permanent occlusion.

• Zhaokang Cheng, Lailiang Ou, +7 authors Gustav Steinhoff
• Cardiovascular research
• 2008

AIMS Controversy exists regarding the effects of granulocyte colony-stimulating factor (G-CSF) on post-infarction remodelling, which is regulated by matrix metalloproteinases (MMPs) and tissue… (More)

10 years of intracoronary and intramyocardial bone marrow stem cell therapy of the heart: from the methodological origin to clinical practice.

• Bodo Eckehard Strauer, Gustav Steinhoff
• Journal of the American College of Cardiology
• 2011

Intracoronary and intramyocardial stem cell therapy aim at the repair of compromised myocardium thereby--as a causal treatment--preventing ventricular remodeling and improving overall performance.… (More)

Intramyocardial bone marrow stem cell transplantation during coronary artery bypass surgery: A Meta-analysis

• Peter Donndorf, Guenther Kundt, +4 authors Gustav Steinhoff
• 2011

Identification of noncytotoxic and IL-10-producing CD8+AT2R+ T cell population in response to ischemic heart injury.

• Caterina Curato, Svetlana Slavic, +11 authors Jun Li
• Journal of immunology
• 2010

Emerging evidence suggests a cardioprotective role of the angiotensin AT2R, albeit the underlying cellular mechanisms are not well understood. We aimed in this article to elucidate a potential role… (More)

Ischemic acidosis causes apoptosis in coronary endothelial cells through activation of caspase-12.

• Sanjeev Kumar, Sascha Andreas Kasseckert, +7 authors Yury Ladilov
• Cardiovascular research
• 2007

OBJECTIVE Myocardial ischemia has been shown to induce apoptosis of endothelial cells (EC). However, the mechanism of this endothelial injury is still poorly understood. To analyse the signaling… (More)

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