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We have modeled an MTBP-MDM2-p53 regulatory network by integrating p53-MDM2 autoregulatory model (Proctor and Gray, 2008) with the effect of a cellular protein MTBP (MDM2 binding protein) which is… (More)
The integration of calcium and a p53-Mdm2 oscillator model is studied using a deterministic as well as a stochastic approach, to investigate the impact of a calcium wave on single cell dynamics and… (More)
We study transition of the temporal behaviours of p53 and MDM2 in a stress p53-MDM2-NO regulatory network induced by a bioactive molecule NO (Nitric Oxide). We further study synchronization among a… (More)
We examine the synchrony in the dynamics of localized [Ca2 + ]i oscillations among a group of cells exhibiting such complex Ca2 + oscillations, connected in the form of long chain, via diffusing… (More)
We study the efficiency of synchronization in ensembles of identical coupled stochastic oscillator systems. By deriving a chemical Langevin equation, we measure the rate at which the systems… (More)
We study how the temporal behaviours of p53 and MDM2 are affected by stress inducing bioactive molecules NO (Nitric Oxide) in the p53-MDM2-NO regulatory network. We also study synchronization among a… (More)