Gurri H Olafsdottir

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Germ-line changes in the cancer-predisposition gene BRCA2 are found in a small proportion of breast cancers. Mutations in the BRCA2 gene have been studied mainly in families with high risk of breast cancer in females, and male breast cancer also has been associated with BRCA2 mutations. The importance of germ-line BRCA2 mutations in individuals without a(More)
The BRCA2 gene on chromosome 13 has been shown to be associated with familial male and female breast cancer. Here we describe a study on BRCA2 in 21 Icelandic families, including 9 with male breast cancer. We have previously reported linkage to the BRCA2 region in an Icelandic male breast cancer family and subsequently found a strong indication of linkage(More)
BACKGROUND Estimates of an 80-90% risk of breast cancer for carriers of germline mutations in the BRCA1 and BRCA2 genes are based on studies of families at high risk of breast cancer. Risk estimates for a population are possible if the mutation status of a representative sample of that population can be assessed. In Iceland, one common founder BRCA2(More)
PURPOSE To assess the risk of death in patients who survive more than 5 years after diagnosis of childhood cancer and to evaluate causes of death in fatal cases. PATIENTS AND METHODS This was a population-based study in the five Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) using data of the nationwide cancer registries and the(More)
BACKGROUND The Icelandic breast cancer screening program, initiated November 1987 in Reykjavik and covering the whole country from December 1989, comprises biennial invitation to mammography for women aged 40-69 years old. PURPOSE To estimate the impact of mammography service screening in Iceland on deaths from breast cancer. MATERIAL AND METHODS Cases(More)
OBJECTIVE To estimate the risk of malignant diseases in families of probands with the same mutation in the BRCA2 gene. DESIGN A cohort study using record linkage of a breast cancer family resource and the Icelandic Cancer Registry. SETTING Iceland. SUBJECTS Families of 995 breast cancer patients, from which 887 were tested for a single founder 999del5(More)
This paper presents evidence from Iceland which indicates that papillary thyroid carcinoma occurs in certain families more often than expected. Thyroid carcinoma was also seen to coexist with some other cancer types more often than expected. We studied all families (n = 373) with papillary thyroid carcinoma diagnosed between 1955 and 1984 in Iceland.(More)
Gastric carcinomas in 382 patients were studied histologically and the results from the preoperative endoscopic biopsies were compared with those from the resected specimens. Using the Laurén classification an overall histological diagnostic agreement between the two specimens was reached in 317 cases, or 83%. The highest diagnostic agreement, 87%, was for(More)
OBJECTIVE To investigate the risk of prostate, ovarian, and endometrial cancer among relatives of patients with breast cancer. DESIGN Cohort study of 947 pedigrees in which the proband had breast cancer, linked with the Icelandic cancer registry. SETTING Iceland. SUBJECTS The 947 pedigrees included 29,725 people, of whom 1539 had breast cancer, 467(More)
Breast cancer is rare in men, and family history of the disease is a risk factor. The recently discovered BRCA2 gene on chromosome 13q is thought to account for some families with increased risk of breast cancer, including male breast cancer. We describe a family with multiple cases of male breast cancer but, interestingly, no increase in female breast(More)