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Clear cell renal cell carcinoma (ccRCC) is the most common form of adult kidney cancer, characterized by the presence of inactivating mutations in the VHL gene in most cases, and by infrequent somatic mutations in known cancer genes. To determine further the genetics of ccRCC, we have sequenced 101 cases through 3,544 protein-coding genes. Here we report(More)
The catalogue of Somatic Mutations in Cancer (COSMIC) (http://www.sanger.ac.uk/cosmic/) is the largest public resource for information on somatically acquired mutations in human cancer and is available freely without restrictions. Currently (v43, August 2009), COSMIC contains details of 1.5-million experiments performed through 13,423 genes in almost(More)
Materials/Methods – Genomic DNA samples were obtained from cancer cell lines or from patient samples as indicated. Collection and use of patient samples were approved by the IRB of each institution in addition to the study having LREC approval locally. Cancer cell lines and clinical samples screened are given in Supplemental Tables 1 and 2, respectively.(More)
Background. COSMIC (http://www.sanger.ac.uk/cosmic) is a system designed to curate the world's literature on somatic mutations in known cancer genes. Initially conceived to capture the mutation spread in point-mutated genes, COSMIC has now grown to encompass gene fusion products of genome rearrangement events which generate completely novel transcripts,(More)
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