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Characterizing the key determinants of variability in the exposure of orally administered drugs may be important in understanding the implications of exposure variability on clinical responses. In particular, partitioning overall variability into interoccasion variability (IOV) and interindividual variability (IIV) allows a better assessment of the clinical(More)
. All righ ence Fou div jruj ru þ juj u 1⁄4 QðxÞ f ðuÞ þ egðuÞ 1⁄2 x 2 R ; u P 0; uðxÞ ! 0 as jxj ! 1: >: By using variational methods and the non-smooth version symmetric criticality principle, we establish (a) the unperturbed problem P0 has infinitely many distinct solutions; (b) the number of distinct solutions for Pe becomes greater and greater whenever(More)
Therapeutic oligonucleotides (OGNs) have been studied extensively in the recent years as novel agents designed to selectively and specifically inhibit target gene expression in cell culture, in animal disease models and in human. This review summarizes applications of liquid chromatography coupled with mass spectrometry or tandem mass spectrometry (LC-MS or(More)
OBJECTIVE This clinical study was designed to learn the diagnosis and treatment of lip carcinoma developing in discoid lupus erythematosus. METHODS One hundred and eighty-one of squamous cell carcinoma of the lips treated in our department from 1980 to 1995 were retrospectively studied. RESULTS Ten cases of the 181 lip carcinoma (5.5%) had concomitant(More)
OBJECTIVE To study the role of mitogen-activated protein kinase (MAPK) pathway in the action mechanism of PYM-induced KB cell apoptosis. METHODS Western blot analysis was used to investigate the expression of the mitogen-activated protein kinase. RESULTS When treated with PYM in cultured KB cells, the extracellular signal-regulated kinase (ERKl/2)(More)
In this work, we study the existence of nodal solutions for the following problem:  φp(u′) ′ + λa(t)f (u) = 0, t ∈ (0, 1), u(0) = u(1) = 0, where φp(s) = |s |p−2 s, a ∈ C([0, 1], [0, +∞)) with a ≢ 0 on any subinterval of [0, 1] and f : R → R is continuous with f (s)s > 0 for s ≠ 0. We give the intervals for the parameter λ which ensure the existence of(More)
In this paper, we use bifurcation method to investigate the existence and multiplicity of one-sign solutions of the p-Laplacian involving a linear/superlinear nonlinearity with zeros. To do this, we first establish a bifurcation theorem from infinity for nonlinear operator equation with homogeneous operator. To deal with the superlinear case, we establish(More)
In this paper, we study a class of nonlocal semilinear elliptic problems with inhomogeneous strong Allee effect. By means of variational approach, we prove that the problem has at least two positive solutions for large λ under suitable hypotheses about nonlinearity. We also prove some nonexistence results. In particular, we give a positive answer to the(More)
* Correspondence: daiguowei2009@126.com Department of Mathematics, Northwest Normal University, Lanzhou 730070, P. R. China Abstract In this article, we study the existence and multiplicity of positive solutions for the Neumann boundary value problems involving the p(x)-Kirchhoff of the form ⎪⎨⎪⎩ −M (∫ 1 p(x) (|∇u|p(x) + λ|u|p(x))dx ) (div (|∇u|p(x)−2∇u) −(More)