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Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, ChineseExpand
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Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans
Circulating trimethylamine N-Oxide (TMAO) levels predict cardiovascular disease (CVD), possibly by impacting on cholesterol metabolism and oxidative stress. Because hepatic TMAO production isExpand
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A support vector machine-recursive feature elimination feature selection method based on artificial contrast variables and mutual information.
Filtering the discriminative metabolites from high dimension metabolome data is very important in metabolomics study. Support vector machine-recursive feature elimination (SVM-RFE) is an efficientExpand
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Analytical strategies in lipidomics and applications in disease biomarker discovery.
Lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. Recently, lipid profiling, or so-called lipidomics research, has capturedExpand
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Urinary metabonomic study of lung cancer by a fully automatic hyphenated hydrophilic interaction/RPLC-MS system.
Lung cancer is one of the most common and lethal cancers in the world. In this study, a home-devised hydrophilic interaction chromatography/RPLC-MS (HILIC/RPLC-MS) system was developed to study theExpand
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Discovery and validation of plasma biomarkers for major depressive disorder classification based on liquid chromatography-mass spectrometry.
Major depressive disorder (MDD) is a debilitating mental disease with a pronounced impact on the quality of life of many people; however, it is still difficult to diagnose MDD accurately. In thisExpand
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Circulating Lysophosphatidylcholines Are Markers of a Metabolically Benign Nonalcoholic Fatty Liver
OBJECTIVE Nonalcoholic fatty liver (NAFL) is thought to contribute to insulin resistance and its metabolic complications. However, some individuals with NAFL remain insulin sensitive. MechanismsExpand
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Effects of pre-analytical processes on blood samples used in metabolomics studies
We present a review of the preanalytical phase of liquid chromatography–mass spectrometry-driven metabolomics analysis of body fluids. Expand
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Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics.
A comprehensive metabonomic method, in combination with fingerprint analysis and target analysis, was performed to reveal potential mechanisms of berberine action in the treatment of patients withExpand
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Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment
Antidiabetic medication may modulate the gut microbiota and thereby alter plasma and faecal bile acid (BA) composition, which may improve metabolic health. Here we show that treatment with Acarbose,Expand
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