Guoping Lian

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Binding of epigallocatechin gallate (EGCG) to highly purified short side-chain porcine gastric mucin similar to human MUC6 type has been studied by ultraviolet-visible absorption spectroscopy (UV-vis), ultrafiltration isothermal titration microcalorimetry (ITC) and transmission electron microscopy (TEM). The thermodynamic equilibrium of EGCG binding to(More)
A number of mathematical models have been proposed for predicting skin permeability, mostly empirical and very few are deterministic. Early empirical models use simple lipophilicity parameters. The recent trend is to use more complicated molecular structure descriptors. There has been much debate on which models best predict skin permeability. This article(More)
Understanding the permeation of hydrophilic molecules is of relevance to many applications including transdermal drug delivery, skin care as well as risk assessment of occupational, environmental, or consumer exposure. This paper reviews recent advances in modeling skin permeability of hydrophilic solutes, including quantitative structure-permeability(More)
Silicone oil droplets have limited deposition on hair due to electrostatic repulsion with negative surface charge of hair substrates. Aiming to improve silicone deposition on hair substrates, surface properties of uniform-sized silicone oil droplets (produced by membrane emulsification) were modified using layer-by-layer electrostatic deposition. By using(More)
Emulsions are commonly used in foods, pharmaceuticals and home-personal-care products. For emulsion based products, it is highly desirable to control the droplet size distribution to improve storage stability, appearance and in-use property. We report preparation of uniform-sized silicone oil microemulsions with different droplets diameters (1.4-40.0 μm)(More)
We present a compact model describing the laminar flow of viscous multiphase fluids in micro-channel networks. We apply this model to the flow of 2 immiscible fluids representing typically oil and water, in a network of micro-channels comprising one inlet for each fluid splitting into 2 branches meeting at a T-junction, where the 2 phases are combined(More)
The binding property of a number of relatively hydrophilic solutes to native and delipidized stratum corneum (SC) and their partition coefficients to extracted lipid have been measured by equilibration experiments to expand the current database which consisted of mostly hydrophobic solutes. Using the extended database, quantitative structure property(More)
To develop in-silico model for predicting percutaneous absorption and disposition kinetics of chemicals in skin layers so as to facilitate the design of transdermal drug delivery systems and skin care products, and risk assessment of occupational or consumer exposure. A general-purpose computer model for simulating skin permeation, absorption and(More)
The uptake kinetics of five molecules by hair has been measured and the effects of pH and physical chemical properties of molecules were investigated. A theoretical model is proposed to analyze the experimental data. The results indicate that the binding affinity of solute to hair, as characterized by hair–water partition coefficient, scales to the(More)
The purpose was to develop a mechanistic mathematical model for predicting the pharmacokinetics of topically applied solutes penetrating through the skin and into the blood circulation. The model could be used to support the design of transdermal drug delivery systems and skin care products, and risk assessment of occupational or consumer exposure. A(More)