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Targeting the capsid protein of hepatitis B virus (HBV) and thus interrupting normal capsid formation have been an attractive approach to block the replication of HBV viruses. We carried out multidimensional structural optimizations based on the heteroaryldihydropyrimidine (HAP) analogue Bay41-4109 (1) and identified a novel series of HBV capsid inhibitors(More)
Residual periodic errors detected in picometer-level heterodyne interferometers cannot be explained by the model based on double-frequency mixing. A new model is established and proposed in this paper for analysis of these errors. The multi-order Doppler frequency shift ghost beams from measurement beam itself are involved in final interference leading to(More)
Described herein are the discovery and structure-activity relationship (SAR) studies of the third-generation 4-H heteroaryldihydropyrimidines (4-H HAPs) featuring the introduction of a C6 carboxyl group as novel HBV capsid inhibitors. This new series of 4-H HAPs showed improved anti-HBV activity and better drug-like properties compared to the first- and(More)
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