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Fetal growth restriction (FGR) is defined as the failure of fetus to reach its growth potential for various reasons, leading to multiple perinatal complications and adult diseases of fetal origins. Shallow extravillous trophoblast (EVT) invasion-induced placental insufficiency and placental dysfunction are considered the main reasons for idiopathic FGR. In(More)
To investigate the incidence, indications, risk factors and transfusions of peripartum hysterectomy in China. A population-based study was conducted using inpatient records of 38 hospitals between 1 January 2011 and 31 December 2011; multivariate logistic regression analysis was used to identify independent risk factors for peripartum hysterectomy. During(More)
OBJECTIVES The objective of the study was to investigate the relationship of a C825T polymorphism of the gene encoding the G protein beta3 subunit with preeclampsia in a South-West Chinese population. RESULTS In the case-control study which included 221 preeclamptic case subjects and 277 normal control subjects the allele frequency of 825CT in the GNB3(More)
The purpose of the study is to investigate the expression of epithelial sodium channel (ENaC) in normal pregnancy and severe preeclampsia placenta and to explore the underlying mechanism of the relationship between the altered ENaC expression and onset of preeclampsia. Reverse transcription polymerase chain reaction (RT-PCR) and Western blot were used to(More)
BACKGROUND The estrogen receptor alpha gene (ESR1) seems to be a potential candidate in altering risk for preeclampsia due to important estrogenic biological effects. Despite its previously reported association with severe preeclampsia in combined genotype in one selected ethnic group, further studies in other populations are required. The objective of this(More)
Background and Objective To evaluate the impact of blood clearance mechanisms on neurologic damage and functional outcomes after intracerebral hemorrhage (ICH) in rats. Methods A rat model of ICH was established through pre-cannulation and injection of autologous arterial blood into the caudate nucleus. Blood was supplemented with 6-amino-caproic acid (a(More)
OBJECTIVE To explore the impact of maternal hepatitis B surface antigen (HBsAg) carrier status on neonatal outcomes. METHODS A retrospective cohort study was conducted using data from medical records database of six hospitals in China. Information on maternal characteristics and selected neonatal outcomes was retrieved for all women who delivered(More)
Proper physiological function of the ovaries is very important for the entire female reproductive system and overall health. Reactive oxygen species (ROS) are generated as by-products during ovarian physiological metabolism, and antioxidants are indicated as factors that can maintain the balance between ROS production and clearance. A disturbance in this(More)
The perivascular and perineural extension of hematoma has recently been observed in the brain after intracerebral hemorrhage (ICH), which is formed by the leakage of hematoma via the Virchow-Robin spaces (VRS) and the spaces around the nerve fibers (perineurium). The present study investigated the perivascular and perineural extension of a hematoma by(More)
BACKGROUND AND AIMS The catechol-O-methyltransferase (COMT) gene is a potential candidate in altering risk for preeclampsia due to the important enzymatic effects in the metabolism of steroid hormones. It contains a non-synonymous G-A base change at codon 158 in the membrane bound isoform, which leads to a valine-to-methionine amino acid substitution. In(More)