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UNLABELLED Transarterial chemoembolization (TACE) is the current standard of treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). Brivanib, a selective dual inhibitor of vascular endothelial growth factor and fibroblast growth factor signaling, may improve the effectiveness of TACE when given as an adjuvant to TACE. In this(More)
OBJECTIVES To develop a new computer-aided detection scheme to compute a global kinetic image feature from the dynamic contrast enhanced breast magnetic resonance imaging (DCE-MRI) and test the feasibility of using the computerized results for assisting classification between the DCE-MRI examinations associated with malignant and benign tumors. MATERIALS(More)
Dynamic contrast material-enhanced magnetic resonance imaging (DCE-MRI) of breasts is an important imaging modality in breast cancer diagnosis with higher sensitivity but relatively lower specificity. The objective of this study is to investigate a new approach to help improve diagnostic performance of DCE-MRI examinations based on the automated detection(More)
AIM The third interim results of the START trial showed encouraging safety and efficacy profiles, with a median time to progression of 9 months. This subgroup analysis presents results in Chinese patients enrolled in the START trial. MATERIALS & METHODS Sixty two Chinese patients (median age 52 years) with unresectable hepatocellular carcinoma had(More)
The aim of this study is to compare the efficacy of endoluminal ultrasonography (EUS) and spiral computerized tomography (SCT) in preoperative local staging of rectal carcinoma. EUS and SCT were performed prior to surgery in 78 patients with rectal carcinoma. After radical surgery, the preoperative findings were compared with histologic findings on the(More)
PURPOSE To investigate the feasibility of applying a new quantitative image analysis method to improve breast cancer diagnosis performance using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) by integrating background parenchymal enhancement (BPE) features into the decision making process. METHODS A dataset involving 115 DCE-MRI(More)
OBJECTIVE To investigate intratumoral microvessel density (MVD) and expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (BFGF) in hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) and to evaluate their significance. METHODS MVD and expression of VEGF and BFGF in cancerous tissues(More)
We report data from the final analysis of the Chinese subset of the GIDEON (the Global Investigation of therapeutic DEcisions in hepatocellular carcinoma and Of its treatment with sorafeNib) study, which evaluated the safety and efficacy of sorafenib in Child-Pugh A, B and C patients with unresectable hepatocellular carcinoma (uHCC) in real-life clinical(More)
Triple-negative breast cancer (TNBC) constitutes ~10-15% of breast cancer patients and represents an aggressive subtype with poor overall prognosis. TNBC is an important clinical challenge because it does not respond well to endocrine therapy and have a higher rate of early recurrence and distant metastasis following chemotherapy. Although it has been(More)
BACKGROUND Through analyzing apparent diffusion coefficient (ADC) values and morphological evaluations, this research aimed to study how magnetic resonance imaging (MRI)-based breast lesion characteristics can enhance the diagnosis and prognosis of breast cancer. METHODS: A total of 118 breast lesions, including 50 benign and 68 malignant lesions, from(More)