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Protein phosphorylation plays a fundamental role in most of the cellular regulatory pathways. Experimental identification of protein kinases' (PKs) substrates with their phosphorylation sites is labor-intensive and often limited by the availability and optimization of enzymatic reactions. Recently, large-scale analysis of the phosphoproteome by the mass(More)
—In this paper, we consider the scenario that a population-based algorithm is applied to a numerical optimization problem and a solution needs to be presented within a given time budget. Although a wide range of population-based algorithms, such as evolutionary algorithms, particle swarm optimizers, and differential evolution, have been developed and(More)
—Estimation of distribution algorithms (EDAs) are widely used in stochastic optimization. Impressive experimental results have been reported in the literature. However, little work has been done on analyzing the computation time of EDAs in relation to the problem size. It is still unclear how well EDAs (with a finite population size larger than two) will(More)
Complex features, such as temporal dependencies and numerical cost constraints, are hallmarks of real-world planning problems. In this article, we consider the challenging problem of cost-sensitive temporally expressive (CSTE) planning, which requires concurrency of durative actions and optimization of action costs. We first propose a scheme to translate a(More)
Web content structure is proposed to facilitate automatic web page adaptation in this paper. By identifying the logic relationship of web content based on layout information, web content structure effectively represents au-thors' presentation intention. An automatic top-down, tag-tree independent approach to detect web content structure is presented. It(More)
In the past decades, many theoretical results related to the time complexity of evolutionary algorithms (EAs) on different problems are obtained. However, there is not any general and easy-to-apply approach designed particularly for population-based EAs on unimodal problems. In this paper, we first generalize the concept of the takeover time to EAs with(More)