Guojie Wang

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Ultraviolet radiation resistance-associated gene (UVRAG) is a well-known regulator of autophagy by promoting autophagosome formation and maturation. Multiple studies have implicated UVRAG in the pathogenesis of colorectal cancer. However, the mechanisms underlying the regulation of UVRAG are unclear. Here, we describe miR-183 as a new autophagy-inhibiting(More)
The presence of data gaps is always a concern in geophysical records, creating not only difficulty in interpretation but, more importantly, also a large source of uncertainty in data analysis. Filling the data gaps is a necessity for use in statistical modeling. There are numerous approaches for this purpose. However, particularly challenging are the(More)
Built-in detector: A quaternized copolymer containing pyrene is described, which can bind to single-stranded DNA by electrostatic interactions to form a novel complex probe for the detection of DNA hybridization through strengthened fluorescence quenching through its intercalation into double-stranded DNA (see figure).
INTRODUCTION Combination therapy with multiple therapeutic agents has wide applicability in medical and surgical treatment, especially in the treatment of cancer. Thus, new drug delivery systems that can differentially release two or more drugs are desired. Utilizing new techniques to engineer the established drug delivery systems and synthesizing new(More)
The drawbacks of poloxamer hydrogel, such as dissolving quickly in aqueous solution, have limited its biomedical application. In order to improve the stability of hydrogel, a novel system was developed by combining the reversible thermo-sensitive property of poloxamer 407 and the thiol-ene reactivity between the acrylate and thiol groups. It was found that(More)
CuS NCs were synthesized via a facile sol-gel method without post-thermal treatment. The as-prepared CuS NCs were analyzed and confirmed by XRD, HR-TEM, EDS and XPS as hexagonal covellite CuS. The average diameter of the samples was about 3nm with narrow size distribution. CuS NCs can form a thin and smooth film without ligand-exchange that can be used as(More)
Combination chemotherapy has been a primary management for cancer. Thus a drug delivery system which can administer several drugs simultaneously and control the drug release at the cancer site is desired. Here we synthesized hyperbranched poly(amine-ester) (HPAE) macromers with different degrees of terminal CC modification to make injectable hydrogels as a(More)