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An elusive goal for systemic drug delivery is to provide both spatial and temporal control of drug release. Liposomes have been evaluated as drug delivery vehicles for decades, but their clinical significance has been limited by slow release or poor availability of the encapsulated drug. Here we show that near-complete liposome release can be initiated(More)
Lung surfactant (LS) and albumin compete for the air-water interface when both are present in solution. Equilibrium favors LS because it has a lower equilibrium surface pressure, but the smaller albumin is kinetically favored by faster diffusion. Albumin at the interface creates an energy barrier to subsequent LS adsorption that can be overcome by the(More)
The cell membrane separates the interior of the cell from the outside and regulates the molecular and ionic content of the intracellular medium. The majority of the energy required to sustain cellular function is expended in maintaining large differences in ion concentrations across the cell membrane. The lipid bilayer provides the ionic diffusion barrier(More)
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