Learn More
Data-intensive applications that operate on large volumes of data have motivated a fresh look at the design of data center networks. The first wave of proposals focused on designing pure packet-switched networks that provide full bisection bandwidth. However, these proposals significantly increase network complexity in terms of the number of links and(More)
—Cloud computing services allow users to lease computing resources from large scale data centers operated by service providers. Using cloud services, users can deploy a wide variety of applications dynamically and on-demand. Most cloud service providers use machine virtualization to provide flexible and cost-effective resource sharing. However, few studies(More)
Many distributed systems rely on neighbor selection mechanisms to create overlay structures that have good network performance. These neighbor selection mechanisms often assume the triangle inequality holds for Internet delays. However, the reality is that the triangle inequality is violated by Internet delays. This phenomenon creates astrange environment(More)
Understanding the characteristics of the Internet delay space (i.e., the all-pairs set of static round-trip propagation delays among edge networks in the Internet) is important for the design of global-scale distributed systems. For instance, algorithms used in overlay networks are often sensitive to violations of the triangle inequality and to the growth(More)
The endoplasmic reticulum (ER) is the cellular organelle responsible for protein folding and assembly, lipid and sterol biosynthesis, and calcium storage. The unfolded protein response (UPR) is an adaptive intracellular stress response to accumulation of unfolded or misfolded proteins in the ER. In this study, we show that the most conserved UPR sensor(More)
UNLABELLED cAMP responsive element-binding protein, hepatocyte specific (CREBH), is a liver-specific transcription factor localized in the endoplasmic reticulum (ER) membrane. Our previous work demonstrated that CREBH is activated by ER stress or inflammatory stimuli to induce an acute-phase hepatic inflammation. Here, we demonstrate that CREBH is a key(More)
Recently, general-purpose computing on graphics processing units (GPGPU) has been enabled on mobile devices thanks to the emerging heterogeneous programming models such as OpenCL. The capability of GPGPU on mobile devices opens a new era for mobile computing and can enable many computationally demanding computer vision algorithms on mobile devices. As a(More)
Recent proposals to build hybrid electrical (packet-switched) and optical (circuit switched) data center interconnects promise to reduce the cost, complexity, and energy requirements of very large data center networks. Supporting realistic traffic patterns, however, exposes a number of unexpected and difficult challenges to actually deploying these systems(More)
Recent advances of software defined networking and optical switching technology make it possible to program the network stack all the way from physical topology to flow level traffic control. In this paper, we leverage the combination of SDN controller with optical switching to explore the tight integration of application and network control. We(More)