Living organisms produce a range of secondary metabolites with exotic chemical structures and diverse metabolic origins. Many of these secondary metabolites find use as natural products in medicine,… (More)
Jadomycin B is a member of atypical angucycline antibiotics whose biosynthesis involves a unique ring opening C-C bond cleavage reaction. Here, we firmly identified JadG as the enzyme responsible for… (More)
Jadomycin production is under complex regulation in Streptomyces venezuelae. Here, another cluster-situated regulator, JadR*, was shown to negatively regulate jadomycin biosynthesis by binding to… (More)
In this paper, the upconversion luminescent properties of Gd2O3:Er3+,Yb3+ nanowires as a function of Yb concentration and excitation power were studied under 978-nm excitation. The results indicated… (More)
The biosynthesis of diazobenzofluorene kinamycins requires a hitherto uncharacterized B-ring contraction. Via detailed genetic and enzymatic analyses we unambiguously characterized the conserved… (More)
C-C bond ring cleaving oxygenases represent a unique family of enzymes involved in the B ring cleavage reaction only observed in atypical angucycline biosynthesis. B ring cleavage is the key reaction… (More)
One-dimensional pure cubic Y(2)O(3)/Eu(3+) nanocrystals (NCs) were synthesized by a hydrothermal method at various temperatures. The NCs prepared at 130 degrees C yielded nanotubes (NTs) with wall… (More)
Proceedings of the National Academy of Sciences…
2014
The angucycline antibiotic jadomycin B (JdB) produced by Streptomyces venezuelae has been found here to induce complex survival responses in Streptomyces coelicolor at subinhibitory concentration.… (More)
Ln3+ doped (Yb3+,Tm3+ codoped and Yb 3+,Er3+,Tm3+ tridoped) NaYF4/poly(vinyl pyrrolidone)(PVP) ( Mw ≈ 1 300 000) composite fibers with an average diameter of 300 -800 nm were prepared by… (More)
Proceedings of the National Academy of Sciences…
2017
Nature's ability to generate diverse natural products from simple building blocks has inspired combinatorial biosynthesis. The knowledge-based approach to combinatorial biosynthesis has allowed the… (More)