Guohua Lei

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The fusion of lipid bilayers can be visualized under the fluorescence microscope, but the process is very fast and requires special techniques for its study. It is reported here that vesicle fusion is susceptible to analysis by microspectrofluorometry and that for the first time, the entire fusion process has been captured. In the case of giant (>10- micro(More)
Homeostasis of the endoplasmic reticulum (ER) is essential for normal cellular functions. Disturbance of this homeostasis causes ER stress and activates the Unfolded Protein Response (UPR). The Ufm1 conjugation system is a novel Ubiquitin-like (Ubl) system whose physiological target(s) and biological functions remain largely undefined. Genetic study has(More)
C53/LZAP (also named as Cdk5rap3) is a putative tumor suppressor that plays important roles in multiple cell signaling pathways, including DNA damage response and NF-kappaB signaling. Yet how its function is regulated remains largely unclear. Here we report the isolation and characterization of two novel C53/LZAP-interacting proteins, RCAD (Regulator of(More)
This paper reports our participation of CEAS Spam-filter Challenge 2008. The logistic regression model, n-gram and TONE (Train On /Near Error) were used to build the systems. We improved the weighting method which reduces the impact of the features appearing both in spam messages and ham messages.. We achieved competitive results in all tasks and got the(More)
Oppositely charged giant vesicles are known to adhere, hemifuse and fuse, all of which depend upon the nature of surface contacts. To further understand such interactions, vesicles were surface-modified with polyethylene glycol (PEG), a moiety that reduces surface-surface interactions. Positively charged vesicles were composed of(More)
HIT2 Lab participated in NTCIR 7 IR4QA task. In this task many topics consist of name entities, so Google translation was used to translate query terms because of its high performance on name entity translation. We use KL-divergence model to perform retrieval and Chinese character bigram as our indexing unit. Pseudo feedback was used trying to improve(More)
This is the first time HIT 2 Lab has participated in CLEF. The Adhoc TEL task used a collection of electronic card catalog records from British Library, it is different from all the text retrieval tasks we've ever involved. In our runs, we used language modeling approach for retrieval model and incorporated pseudo-feedback, which have been proved effective(More)
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