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OBJECTIVE The effect of transplanted mesenchymal stem cells (MSCs) on the left ventricular (LV) function and morphology in a rat myocardial infarct heart with reperfusion model were analyzed. METHODS One week after 60 min of myocardial ischemia and reperfusion by left anterior descending artery (LAD) occlusion, 1.0x10(7) 6-diamidino-2-phenylindole(More)
Glucocorticoids (GCs) have both anabolic and catabolic effects on bone. However, no GC anabolic effect mediator has been identified to date. Here we show that targeted expression of glucocorticoid-induced leucine zipper (GILZ), a GC anti-inflammatory effect mediator, enhances bone acquisition in mice. Transgenic mice, in which the expression of GILZ is(More)
BACKGROUND Eight percent of the U.S. population has been diagnosed with diabetes mellitus (DM), while another large percentage has gone undiagnosed. As the epidemiology of this disease constitutes a larger percentage of the American population, another factor presents a dangerous dilemma that can exacerbate the hazardous effects imposed by DM. Excessive(More)
Stem/progenitor cells from multiple tissues have been isolated based on enhanced activity of cytosolic aldehyde dehydrogenase (ALDH) enzyme. ALDH activity has emerged as a reliable marker for stem/progenitor cells, such that ALDH(bright/high) cells from multiple tissues have been shown to possess enhanced stemness properties (self-renewal and multipotency).(More)
Reactive oxygen species (ROS)-mediated reactive aldehydes induce cellular stress. In cardiovascular diseases such as ischemia-reperfusion injury, lipid-peroxidation derived reactive aldehydes such as 4-hydroxy-2-nonenal (4HNE) are known to contribute to the pathogenesis. 4HNE is involved in ROS formation, abnormal calcium handling and more importantly(More)
This paper studies the problem of multi-body segmentation and motion number estimation. It is well known that motion number plays a critical role in the success of multi-body segmentation. Most of the existing methods exploit only motion affinity to segment and determine the number of motions. Motion number estimated in this way is often seriously affected(More)
Aldehyde dehydrogenase (ALDH) gene superfamily consists of 19 isozymes. They are present in various organs and involved in metabolizing aldehydes that are biologically generated. For instance, ALDH2, a cardiac mitochondrial ALDH isozyme, is known to detoxify 4-hydroxy-2-nonenal, a reactive aldehyde produced upon lipid peroxidation in diabetic conditions. We(More)
The mean shift algorithm is a widely used non-parametric clustering algorithm. It has been extended to cluster a mixture of linear subspaces for solving problems in computer vision such as multibody motion segmentation, etc. Existing methods only work with a set of subspaces, which are computed from samples of observations. However, noises from observations(More)
Estimation of local multiple orientations plays an important role in many image processing and computer vision tasks. It has been shown that the detection of orientations in an image patch corresponds to fitting multiple axes to its Fourier transform. In this paper, k-medoids are introduced to detect local multiple orientations in the Fourier domain.(More)