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FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics
TLDR
FGF21, via the AMPK signaling pathway, regulates the senescence of MSCs by mediating mitochondrial dynamics and targeting FGF21 might represent a novel strategy to improve the quality and quantity of M SCs. Expand
JAK2/STAT3 pathway is involved in the protective effects of epidermal growth factor receptor activation against cerebral ischemia/reperfusion injury in rats
TLDR
It is implicate that JAK2/STAT3 pathway plays the vital role in I/R injury protection from activating EGFR, and the neuroprotective effects may associate with inhibiting the Cx43 expression and the inhibition of apoptosis. Expand
Influence of gap junction intercellular communication composed of connexin 43 on the antineoplastic effect of adriamycin in breast cancer cells.
TLDR
The cytotoxicity of adriamycin on breast cancer cells was increased when the function of gap junctions was enhanced and the modulation of GJ did not affect the survival of cells treated with adRIamycin when cells were in low density. Expand
Role of gap junction intercellular communication in testicular leydig cell apoptosis induced by oxaliplatin via the mitochondrial pathway.
TLDR
In testicular leydig normal/cancer cells, GJIC plays an opposite role in oxaliplatin‑induced apoptosis via the mitochondrial pathway, which is correlated with the mitochondrial pathways-related protein Bcl-2/Bax and caspase‑3/9. Expand
[Expression of connexin 43 and functional modulation of gap junction in neonatal rat astrocytes in vitro].
TLDR
ATRA and oleamide can modulate gap junction intercellular communication of the astrocytes possibly by regulating the expression of Cx43 protein. Expand
Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways
TLDR
Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways. Expand
Total flavonoids of litsea coreana enhance the cytotoxicity of oxaliplatin by increasing gap junction intercellular communication.
TLDR
It is demonstrated that total flavonoids of litsea coreana (TFLC) can enhance the cytotoxicity of oxaliplatin, and that these processes may be regulated in testicular tumor cells through GJ-mediated regulation of tumor cell apoptosis. Expand
Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Abdominal Aortic Aneurysm Exhibit Senescence Phenomena
TLDR
This study showed that AAA-ASCs exhibit senescence phenomena and decreased cell function, which will help explore novel strategies to restore cell function for AAA treatment. Expand
miR‐155‐5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction
TLDR
This study shows that miR‐155‐5p mediates MSC senescence by regulating the Cab39/AMPK signaling pathway and miR •155‐ 5p is a novel target to rejuvenate AMSCs and enhance their cardioprotective effects. Expand
[Baicalein enhances the gap junction in the TM4 Sertoli cells of mice].
TLDR
Baicalein at the concentration of 0-20 µmol/L can significantly enhance GJIC in mouse TM4 Sertoli cells by increasing the expression of the Cx43 protein. Expand
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