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Salicylic acid activates artemisinin biosynthesis in Artemisia annua L.
Results suggest that salicylic acid induces artemisinin biosynthesis in Artemisia annua L. annua in at least two ways: by increasing the conversion of dihydroartemisinic acid into artemis inin caused by the burst of ROS, and by up-regulating the expression of genes involved in artemisine biosynthesis. Expand
High efficiency of genetic transformation and regeneration of Artemisia annua L. via Agrobacterium tumefaciens-mediated procedure
- Jun-li Han, Hong Wang, +6 authors Guo-feng Li
In this work, experiments with different combinations of hormone concentration were performed to obtain higher frequency of shoot and root induction and a system of high efficiency of genetic transformation and regeneration of A. annua was established. Expand
Foliar application of chitosan activates artemisinin biosynthesis in Artemisia annua L.
It is shown that foliar application of 100 mg l−1 chitosan improved artemisinin biosynthesis in A. annua and induced the expression of ADS and DBR2, which could explain the increase in level of artemisinic metabolites. Expand
Effects of Overexpression of the Endogenous Farnesyl Diphosphate Synthase on the Artemisinin Content in Artemisia annua L.
Artemisinin is a novel effective antimalarial drug extracted from the medicinal plant Artemisia annua L. Owing to the tight market and low yield of artemisinin, there is great interest in enhancing… Expand
Evaluation of Paeonol Skin-Target Delivery from Its Microsponge Formulation: In Vitro Skin Permeation and In Vivo Microdialysis
The aim of the present study was to design a novel topical skin-target drug-delivery system, the paeonol microsponge, and to investigate its drug-release patterns in dosage form, both in vitro and in… Expand
Artemisinin biosynthesis enhancement in transgenic Artemisia annua plants by downregulation of the β-caryophyllene synthase gene.
It is demonstrated that the inhibition pathway in the precursor competition for artemisinin biosynthesis by anti-sense technology is an effective means of increasing the art Artemisinin content of A. annua plants. Expand
Hundred top-cited articles focusing on acute kidney injury: a bibliometric analysis
This study provides a historical perspective on the scientific progress on AKI, and highlights areas of research requiring further investigations and developments. Expand
Afatinib reverses multidrug resistance in ovarian cancer via dually inhibiting ATP binding cassette subfamily B member 1
Combining afatinib with chemotherapeutic drugs in ovarian cancer can facilitate the rediscovery of superior MDR reversal agents from molecular targeted drugs to provide a more effective and safer way of resensitizing MDR. Expand
A novel type III polyketide synthase encoded by a three-intron gene from Polygonum cuspidatum
RNA gel blot analysis revealed that PcPKS2 is highly expressed in the rhizomes and in young leaves, but not in the roots of the plant, and type III PKS genes studied so far contained only one intron at a conserved site in flowering plants. Expand
Studies on the effects of fpf1 gene on Artemisia annua flowering time and on the linkage between flowering and artemisinin biosynthesis.
Results showed that flowering is not a necessary factor for increasing the artemisinin content, furthermore, there may be no direct linkage between flowering and art Artemisinin biosynthesis. Expand