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Folate fortification of rice by metabolic engineering
TLDR
F folate biofortification of rice seeds is achieved by overexpressing two Arabidopsis thaliana genes of the pterin and para-aminobenzoate branches of the folate biosynthetic pathway from a single locus. Expand
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer
TLDR
It is concluded that combinations of pharmacologic inhibitors that concurrently block both ERK MAPK and autophagic processes that are upregulated in response to ERK inhibition may be effective treatments for PDAC. Expand
pH stability of individual folates during critical sample preparation steps in prevision of the analysis of plant folates.
TLDR
An LC-MS/MS method with isotopically labelled 5-methyltetrahydrofolate and folic acid as internal standards has been developed with enhanced sensitivity using a Chromolith RP-18 column and provides useful information for the analysis of folates in the future as well as for the interpretation of quantitative results from earlier work. Expand
The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.
TLDR
These studies identify BDK and PPM1K as a ChREBP-regulated node that integrates BCAA and lipid metabolism and manipulation of the BDK:P PM1K ratio relieves key metabolic disease phenotypes in a genetic model of severe obesity. Expand
Quantitative analysis of twelve sulfonamides in honey after acidic hydrolysis by high-performance liquid chromatography with post-column derivatization and fluorescence detection.
TLDR
Post-column derivatization with fluorescamine proved to be a reproducible derivatized technique enabling a sensitive and rugged quantitative determination of sulfonamides, demonstrating good intra- and interbatch precision and accuracy. Expand
Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
TLDR
Oncogenic PIK3CA mutations are established as a cause of glutamine dependency in CRCs and targeting glutamine metabolism may be an effective approach to treat CRC patients harbouring PIK1–RSK2–ATF4 mutations. Expand
Interrelations between C4 Ketogenesis, C5 Ketogenesis, and Anaplerosis in the Perfused Rat Liver*
TLDR
Mass isotopomer analysis of C4 and C5 ketone bodies and of related acyl-CoA esters reveal that C5 and C4 share the same pool of acetyl- CoA. Expand
Cardiovascular Metabolomics
TLDR
This review will discuss the current state of metabolomics technologies, including consideration of various metabolomics platforms and elements of study design; the emerging utility of stable isotopes for metabolic flux studies; and the use of metabolites to better understand specific cardiovascular diseases, with an emphasis on recent advances in the field. Expand
Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4.
TLDR
It is demonstrated that the pluripotency transcription factor OCT4 can serve as a metabolic-redox sensor in hESCs and that metabolic cues can act in concert with growth factor signaling to orchestrate stem cell differentiation. Expand
Regulation of One-Carbon Metabolism in Arabidopsis: The N-Terminal Regulatory Domain of Cystathionine γ-Synthase Is Cleaved in Response to Folate Starvation1[W]
TLDR
It is suggested that a metabolic effector can modulate CGS activity in vivo through an interaction with the N-terminal domain of the enzyme and that removal of this domain can suppress this regulation. Expand
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