Guo-Yuan Zhu

Publications65
h-index18
Citations1,066
Highly Influential Citations43
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Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells.
Through an extensive herbal drug screening program, we found that gomisin A, a dibenzocyclooctadiene compound isolated from Schisandra chinensis, reversed multidrug resistance (MDR) in… Expand
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20(S)-Protopanaxadiol, a metabolite of ginsenosides, induced cell apoptosis through endoplasmic reticulum stress in human hepatocarcinoma HepG2 cells.
20(S)-Protopanaxadiol (PPD), a metabolite of ginsenosides, has been demonstrated to possess cytotoxic effects on several cancer cell lines. The molecular mechanism is, however, not well understood.… Expand
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1alpha,25-Dihydroxyvitamin D3 inhibits transcriptional potential of nuclear factor kappa B in breast cancer cells.
1alpha,25-Dihydroxyvitamin D(3) (VD(3)), the biologically active form of vitamin D, may have either pro- or anti-inflammatory activities because of its diverse actions on nuclear factor kappa B… Expand
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Proteomic identification of proteins involved in the anticancer activities of oridonin in HepG2 cells.
Oridonin is the main bioactive constituent of the Chinese medicinal herb Isodon rubescens and has been shown to have anti-neoplastic effects against a number of cancers in vitro and in vivo. Here we… Expand
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Saussurea involucrata: A review of the botany, phytochemistry and ethnopharmacology of a rare traditional herbal medicine.
ETHNOPHARMACOLOGICAL RELEVANCE Saussurea involucrata Matsum. & Koidz. is an endangered species of the Asteraceae family, growing in the high mountains of central Asia. It has been, and is, widely… Expand
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Cytotoxic dehydromonacolins from red yeast rice.
Two new dehydromonacolins (1 and 3), together with nine known monacolins (4-12), were isolated from red yeast rice. Compounds 4-6 were isolated from a natural resource for the first time. Their… Expand
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7-deacetylgedunin suppresses inflammatory responses through activation of Keap1/Nrf2/HO-1 signaling.
Macrophages play a critical role in a variety of inflammatory diseases. Activation of Keap1/Nrf2/HO-1 signaling results in inactivation of macrophages and amelioration of inflammatory and autoimmune… Expand
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Acylated Protopanaxadiol‐Type Ginsenosides from the Root of Panax ginseng
Six new protopanaxadiol‐type ginsenosides, named ginsenosides Ra4–Ra9 (1–6, resp.), along with 14 known dammarane‐type triterpene saponins, were isolated from the root of Panax ginseng, one of the… Expand
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Dihydro-β-agarofuran sesquiterpene polyesters isolated from the stems of Tripterygium regelii.
Twelve new dihydro-β-agarofuran polyesters, triptregelines A-J (1-3 and 5-11) and triptregelols A, B (4, 12), together with five known ones (13-17) were isolated from the stems of Tripterygium… Expand
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1,25-dihydroxyvitamin D3 induces biphasic NF-kappaB responses during HL-60 leukemia cells differentiation through protein induction and PI3K/Akt-dependent phosphorylation/degradation of IkappaB.
1,25-dihydroxyvitamin D(3) (VD(3)) induces differentiation in a number of leukemia cell lines and under various conditions is able to either stimulate or inhibit nuclear factor kappa B (NF-kappaB)… Expand
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