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Structure of a glutamate-receptor ligand-binding core in complex with kainate
The bilobed structure shows the determinants of receptor–agonist interactions and how ligand-binding specificity and affinity are altered by remote residues and the redox state of the conserved disulphide bond.
AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.
The data strongly suggest that t(8;21) AML follows a stepwise model in leukemogenesis, i.e., AE represents the first, fundamental genetic hit to initiate the disease, whereas activation of the C-KIT pathway may be a second but also crucial hit for the development of a full-blown leukemia.
Functional characterization of a potassium-selective prokaryotic glutamate receptor
GluR0 provides evidence for the missing link between potassium channels and GluRs, and it is suggested that their ion channels have a similar architecture, that GLURs are tetramers and that the gating mechanisms of GluRF and potassium channels have some essential features in common.
Targeted genes and interacting proteins of hypoxia inducible factor-1.
This review will focus on the current knowledge of HIF-1α-targeting genes and its interacting proteins, as well as the concomitant functional relationships between them.
Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths
Surprisingly, mass spectrometry, two-dimensional gel analysis and immunofluorescent experiments revealed that the most frequently used hTERT immunoprobe, a mouse monoclonal antibody that was claimed to be directed against an h TERT protein epitope, in fact recognizes nucleolin rather than telomerase.
RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins
  • Shu Xiao, Dong Li, +9 authors J. Tong
  • Biology, Medicine
    Proceedings of the National Academy of Sciences
  • 31 October 2006
Evidence that ectopic expression of Rig-G in U937 cells can lead to a significant accumulation of cells at G1/S transition is provided and a role of rig-G for c-myc down-regulation that results in an up-regulation of p21, tightly associated with cell cycle arrest is demonstrated.
Expression of anion exchanger 1 sequestrates p16 in the cytoplasm in gastric and colonic adenocarcinoma.
It is concluded that AE1 plays a crucial role in the pathogenesis of gastric and colonic adenocarcinoma and that p16 dysfunction is a novel pathway of carcinogenesis.
Engineering the growth pattern and cell morphology for enhanced PHB production by Escherichia coli
Results demonstrated that a combination of the new division pattern with elongated shape of E. coli improved PHB production and provided a new vision on the enhanced production of inclusion bodies.
Receptor-transporting Protein 1 Short (RTP1S) Mediates Translocation and Activation of Odorant Receptors by Acting through Multiple Steps*
A series of structure-function analyses of RTP1S in HEK293T cells found the N terminus of RTB1S is important for the endoplasmic reticulum exit of ORs and that a middle region of R TP1S are important for OR trafficking from the Golgi to the membrane.
Nicotinic Acid Inhibits Glucose-Stimulated Insulin Secretion Via the G Protein-Coupled Receptor PUMA-G in Murine Islet &bgr; Cells
The results indicated that PUMA-G stimulation by NA in islet &bgr; cells inhibited GSIS likely via activation of the Gi signaling pathway.