Guo-Ping Chen

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BACKGROUND Ezrin is known to regulate cellular survival, adhesion, migration, and invasion and has been identified as 1 of the key components of tumor progression and metastasis. The purpose of this study was to evaluate the clinicopathologic and prognostic significance of ezrin expression in non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS We(More)
Interleukin 17 (IL-17) is a Th17 cytokine associated with inflammation, autoimmunity and defense against some bacteria, it has been implicated in many chronic autoimmune diseases including psoriasis, multiple sclerosis and systemic sclerosis. However, whether IL-17 plays a role in the pathogenesis of systemic lupus erythematosus (SLE) remains unclear. In(More)
OBJECTIVE To evaluate the value of early identification and endovascular treatment of iliac vein compression syndrome (IVCS), with or without deep vein thrombosis (DVT). MATERIALS AND METHODS Three groups of patients, IVCS without DVT (group 1, n = 39), IVCS with fresh thrombosis (group 2, n = 52) and IVCS with non-fresh thrombosis (group 3, n = 34) were(More)
OBJECTIVE To develop a novel method of spinal pedical stereotaxy by reverse engineering and rapid prototyping techniques, and to validate its accuracy by experimental and clinical studies. METHODS A 3D reconstruction model for the desired lumbar vertebra was generated by using the Mimics 10.11 software, and the optimal screw size and orientation were(More)
Tomato (Lycopersicon esculentum Mill.) ripening-associated membrane protein (TRAMP) is a channel protein of the membrane intrinsic protein (MIP) class encoded by the cDNA clone pNY507 [R.G. Fray et al. (1994) Plant Mol Biol 24: 539–543]. It has been suggested that these proteins encode water channels or aquaporins. TRAMP mRNA accumulated in all tomato(More)
OBJECTIVE Sodium aescinate (SA) is used as a vasoactive drug in clinical treatment. This study was designed to investigate the effects of SA on rat isolated thoracic aorta and the possible mechanisms. METHODS Isometric tension was recorded in response to drugs in organ bath. RESULTS The effects of SA obeyed an all-or-nothing response. SA in relatively(More)
Previous clinical and experimental studies have demonstrated that statins, the inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, can improve left ventricular function in damaged hearts. Also, the normal expression of Ca2+ regulatory proteins is critical for efficient myocardial function. However, it is still unclear whether the beneficial(More)
AIM Polysaccharide sulfate (PSS) is a new type of heparinoid synthesized with alginic acid as the basic material and then by chemical introduction of effective groups. Although PSS is successfully applied in ischemic cardio-cerebrovascular disease, its effect on cardiac function after ischemia/reperfusion (I/R) injury has previously not been investigated.(More)
A recombinant plasmid, pRP-GFP, harboring the green fluorescent protein (GFP) gene from the broad-host-range mobilizable plasmid pRK415 of the RK2 family was constructed and transferred by conjugation from Escherichia coli S17-1 to Sorangium cellulosum So ce90. The results of Southern blot analysis showed that the plasmid replicated autonomously without(More)
AIM Cardiovascular remodeling is closely associated with cholesterol and is attenuated by statins. The spontaneously hypertensive rat (SHR) has a low serum cholesterol level and evident cardiovascular remodeling. The aims of the present study were to characterize the effects of atorvastatin on tissue cholesterol content and(More)