Guo Liu

Learn More
Results of various cancer genome sequencing projects have “unexpectedly” challenged the framework of the current somatic gene mutation theory of cancer. The prevalence of diverse genetic heterogeneity observed in cancer questions the strategy of focusing on contributions of individual gene mutations. Much of the genetic heterogeneity in tumors is due to(More)
Mitotic cell death is an important form of cell death, particularly in cancer. Chromosome fragmentation is a major form of mitotic cell death which is identifiable during common cytogenetic analysis by its unique phenotype of progressively degraded chromosomes. This morphology however, can appear similar to the morphology of premature chromosome(More)
Increasing attention is focusing on chromosomal and genome structure in cancer research due to the fact that genomic instability plays a principal role in cancer initiation, progression and response to chemotherapeutic agents. The integrity of the genome (including structural, behavioral and functional aspects) of normal and cancer cells can be monitored(More)
The importance of the chromosome versus the gene as a causative agent in cancer formation has sparked a heated debate. This issue is directly related to two different schools of thought, namely the gene-centric or genome-centric paradigms of cancer research [1–3]. For decades we have essentially ignored the evolutionary nature of complex cancer systems due(More)
Chemosensory proteins (CSPs) are small scavenger proteins that are mainly known as transporters of pheromone/odor molecules at the periphery of sensory neurons in the insect antennae and in the producing cells from the moth female pheromone gland. Sequencing cDNAs of RNA encoding CSPs in the antennae, legs, head, pheromone gland and wings from five single(More)
Current cytogenetics has largely focused its efforts on the identification of recurrent karyotypic alterations, also known as clonal chromosomal aberrations (CCAs). The rationale of doing so seems simple: recurrent genetic changes are relevant for diseases or specific physiological conditions, while non clonal chromosome aberrations (NCCAs) are(More)
© 2013 CSIRO a nd t he B ureau of Meteorology. To the e xtent perm itted by law, a ll rights are reserved and no part of this publ ication covered by copy right may be repro duced or copi ed in any form or by any means except with the written permission of CSIRO and the Bureau of Meteorology. CSIRO and the B ureau of M eteorology advise t hat t he i(More)
(2016). The impact of high and low dose ionising radiation on the central nervous system. Redox Biology, 9, 144-156. <a href="'Fire Mouse': A global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies. functional characterization of a complete PBR/TSPO knockout. (2012). Glutamate potentiates(More)