Gunther Kern

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  • Tomas Lundqvist, Stewart L Fisher, Gunther Kern, Rutger H A Folmer, Yafeng Xue, D Trevor Newton +3 others
  • 2007
Glutamate racemase is an enzyme essential to the bacterial cell wall biosynthesis pathway, and has therefore been considered as a target for antibacterial drug discovery. We characterized the glutamate racemases of several pathogenic bacteria using structural and biochemical approaches. Here we describe three distinct mechanisms of regulation for the family(More)
Fragment-based lead discovery and design has and continues to show increasing promise in drug discovery. In this article, the current state of the art in terms of hot-spot characterization, fragment screening techniques, and fragment-based design is discussed. Three overall fragment-based lead generation strategies are explored and involve the chemical(More)
The phosphate-and oxygen-dependent pyruvate oxi-dase from Lactobacillus plantarum is a homotetrameric enzyme that binds 1 FAD and 1 thiamine diphosphate per subunit. A kinetic analysis of the partial reactions in the overall oxidative conversion of pyruvate to acetyl phosphate and CO 2 shows an indirect activation of the thiamine diphosphate by FAD that is(More)
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