Gunther Gerisch

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Electron tomography of vitrified cells is a noninvasive three-dimensional imaging technique that opens up new vistas for exploring the supramolecular organization of the cytoplasm. We applied this technique to Dictyostelium cells, focusing on the actin cytoskeleton. In actin networks reconstructed without prior removal of membranes or extraction of soluble(More)
Membrane interaction in aggregating cells of Dictyostelium discoideum can be blocked by univalent antibodies directed against specific membrane sites. Using a quantitative technique for measuring cell association, two classes of target sites for blocking antibodies were distinguished and their developmental dynamics studied. One class of these sites is(More)
t u n g s z e i t r a u m yon 3 Woche l i voli IIur e twa 1,3 min . D u r c h die f rak t ion ie r t e D a r r e i c h u n g s f o r m w u r d e n bei d iesen Un te r s u c h u n g e n m i t so ge r ingen L i ch t menge l i W e r t e ge funden , die den im Tages l ich t aufgewachse l ien P f l anzen g le ichkamen . Die V e r w e n d u n g e iner H o c h f r(More)
Phosphorwolf rams~ture besollders deut l ich werden ulld im rech ten Winke l zu den als "p ro jec t ing r idges" [2~ oder "a i le t tes c y t o p l a s m i q u e s " ~1] beze ichne ten Auss t i i lpungel l der Geil3elhiille s t ehen *. Sie inserierell e rs t in einiger E n t f e r n u n g v o n d e r Basis des F lage l lums u n d ers t recken sich wahrsche(More)
(of an individual egg) could be as short as the time needed for the doubling of the largest replicating unit (ap-prox. 4min, Fig. I c). Our finding that 14% of the molecules are in replication is fully compatible with both of these extreme possibilities. When cells of the eukaryotic microorganism Dictyostelium discoideum are repeatedly exposed to electric(More)
Aggregating cells of the cellular slime mold, Dictyostelium discoideum, are guided by an intercellular signal system comprising chemotaxis, cell contact formation and transmission of periodic stimuli from cell to cell. This has been studied as a model system for morphogenetic cell interactions in which spatial patterns are formed by self-organization,(More)
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