Gunnar Sigurðsson

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To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated(More)
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in(More)
We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying(More)
OBJECTIVE Recombinant teriparatide, a bone anabolic agent, is given to treatment-naïve and pre-treated patients with severe osteoporosis, but few data exist comparing the response to teriparatide in these groups. EUROFORS (the EUROpean study of FORSteo‡) enrolled postmenopausal women with established osteoporosis who were either treatment-naïve or had prior(More)
Measurement of bone mineral density (BMD) is the basis of the diagnosis of osteoporosis. WHO classification of osteoporosis is based on dual energy X-ray absorptiometry (DEXA) using the BMD of young women (20-30 years) as the reference value (T-score). For clinical purpose it is better to use age-matched control (Z-score) to evaluate future fracture risk in(More)
BACKGROUND The purpose of this study was to examine the effect of vitamin D intake and production in skin on vitamin D homeostasis in adult Icelanders. METHODS Participants were 30-85 years old, randomly selected from the registry of the Reykjavik area (64 degrees N) and answered a thorough questionnaire on diet and vitamin supplements. Concentrations of(More)
Familial hypercholesterolemia is a genetic disorder causing lifelong elevation of cholesterol and severely increased risk of coronary heart disease. Cholesterol lowering drug treatment is usually effective and clinical trials indicate a substantial lowering of risk, thanks to treatment. The diagnosis is based on cholesterol level in the individual and in(More)
To characterise type 2 diabetes (T2D) associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D cases and 132,532 controls of European ancestry after imputation using the 1000 Genomes multi-ethnic reference panel. Promising association signals were followed-up in additional data(More)
OBJECTIVE It is generally believed that exercise positively influences bone mineral density (BMD). Athletes have been found to have higher BMD than controls but it has proven difficult to reproduce these findings in the general population. RESULTS from cross-sectional studies on the relationship between exercise and BMD in postmenopausal women have been(More)
OBJECTIVE To study physical activity among Icelandic adults and the relationship with anthropometric factors and grip strength. MATERIAL AND METHODS Randomly selected participants, 30-85 years of age, answered questions regarding exercise and diet. Body composition was measured with DXA, which detects the proportions of different body tissues. Height,(More)