Gunnar Müller

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Simple reaction times (RT) to clicks, flashes and numerical signals were measured in four groups of subjects: 21 patients with mild presenile onset dementia of the Alzheimer type (PDAT, mean age 56 years), 14 patients with chronic cardiovascular disease and incipient cognitive deficit (mean age 55 years), 15 healthy older controls (mean age 53 years) and 16(More)
Adult male hooded rats of the Long-Evans strain were investigated before and after lesions of the ventral nucleus reticularis pontis oralis (vRPO) in an open field test (OF) and in a Y-maze. The OF and the neurological findings were scarcely changed. Startle responses were strongly reduced and also horizontal head and body turning in the OF were(More)
Little is known about the impact of cytochrome P450 polymorphisms on the metabolism of trimipramine, which is still widely used as antidepressant due to its positive effect on sleep patterns. A single oral dose of 75 mg trimipramine was given to 42 healthy volunteers selected according to their CYP2D6, CYP2C19, and CYP2C9 genotypes. The reference group(More)
Smooth pursuit eye movements, saccades and eye blinks were electrooculographically recorded from 26 healthy subjects of different age and 35 patients with presumptive presenile onset dementia (mean age 54), who had to track a light spot which oscillated with different speeds. Older subjects (mean age 51) performed the eye tracking with less accuracy and(More)
The clinical diagnosis of organic brain syndromes (especially of primary degenerative dementia) in their early stages is uncertain or only tentative. We used a set of relatively simple tests to support the hypothesis that the disturbance of several operational brain functions precedes memory decline in primary degenerative dementia. Twenty-one patients with(More)
(ger) Abstract (eng) Several studies have demonstrated involvement of the enzymes CYP2D6, CYP2C19 and CYP2C9 in the metabolism of tricyclic antidepressants. We studied the effects of genetic polymorphisms in these enzymes on E-,Z-doxepin and trimipramine pharmacokinetics in humans. A single orale dose of each 75 mg timipramine and doxepin was given to 42(More)
Tactile pattern recognition of ten different patterns which were engraved upon 4 x 4 cm plastic plaquettes with one hand and thereafter drawing with the other or the same hand was tested in 21 patients with a mild stage primary degenerative presenile onset dementia of Alzheimer type (DAT) and in 14 patients with a questionable dementia on the background of(More)
The EEG alpha rhythm suppression by sudden unexpected tones in a relaxed wakefulness state (Berger response) was measured in four groups of patients and healthy control subjects. One patient group with early cognitive deficits probably caused by a mild stage of presenile onset primary degenerative dementia of the Alzheimer type (DAT), a second patient group(More)
The length of upper and lower incisors of Long-Evans hooded rats between gingiva and top were measured before and after small bilateral symmetric electrolytic lesions of the pontine reticular formation between the ventromedial parabrachial nucleus and the motor trigeminal nucleus. Ten days after lesions of this region 8.5 mm posterior to bregma the length(More)