Gunnar Höglund

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Testicular and germ cell line morphology in rats were studied 2 weeks, 10 months and 14 months after cessation of a 61-day inhalation exposure to 1000 ppm n-hexane. Androgen biosynthetic capacity of testis, testosterone blood concentration, vas deferens morphology and noradrenaline (NA) concentration, epididymal sperm morphology, and fertility were also(More)
1. The oxygen consumption of the compound eye in the blowfly was determined during light exposure and in darkness by a manometric measuring technique. Within the first 10 s of exposure to bright white light the oxygen uptake increased up to 20 × the resting value in darkness, which is 2.4 to 3×10−5ml oxygen x min−1 × eye−1. 2. The time course of oxygen(More)
An exposure chamber for microdialysis on awake, freely moving rats during exposure to volatile agents is described. Inhalation exposure to 1000 and 2000 ppm toluene for 2 h was accompanied by an increase in extracellular dopamine levels within the striatum, but did not affect the homovanillic acid level. Neither the dopamine nor the homovanillic acid level(More)
The spectral sensitivity of the visual cells in the compound eye of the mothDeilephila elpenor was determined by electrophysiological mass recordings during exposure to monochromatic adapting light. Three types of receptors were identified. The receptors are maximally sensitive at about 350 nm (ultraviolet), 450 nm (violet), and 525 nm (green). The spectral(More)
Effect of acute inhalation exposure of toluene or halothane anaesthesia on extracellular levels of gamma-aminobutyric acid (GABA) was monitored within the cerebellum of rats by microdialysis. GABA increased during and after exposure to toluene (2000 p.p.m., 2 hr) in contrast, halothane had no noticeable effect on GABA levels. When tetrodotoxin was added to(More)
Rats were exposed to noise (100 dB Leq, 10 h/d, 7 d/w, 4 w), or to toluene (1,000 ppm, 16 h/d, 7 d/w, 2 w), or to noise followed by toluene. Auditory sensitivity was tested before exposure, and 1 to 4 weeks after exposure, by brainstem audiometry using a 1/3-octave filtered sine wave stimulus at the frequencies 1.6, 3.15, 6.3, 12.5 and 20.0 kHz. Some(More)
The potential neurotoxicity of the solvent toluene to the nigrostriatal dopaminergic system was assessed in a rat model of Parkinson's disease. Rats, 1 day after a unilateral injection of 6-hydroxydopamine (6-OH DA) into the substantia nigra, inhaled air or different concentrations of toluene (80, 300 or 1000 ppm), 6 h/day for 3 days. The animals were(More)
Rats were exposed to toluene (1000 ppm, 16 h/d, 5 d/w, 2 w), or noise (100 dB Leq, 10 h/d, 7 d/w, 4 w) or toluene followed by noise. Auditory function was tested by brainstem audiometry using a 1/3 octave filtered sine wave stimulus at the frequencies 1.6, 3.15, 6.3, 12.5 and 20.0 kHz. A high-frequency auditory impairment was observed after exposure to(More)
Two inbred strains of mice, CBA/Ca (with a moderate hearing loss starting late in life) and C57BL/6J (with an early onset of spontaneous auditory degeneration), were exposed to toluene by inhalation (1000 ppm, 12 h/day, 7 days) at either 1 or 6 months of age. Thresholds of auditory brainstem response (ABR) were measured 3–5 days after exposure and assessed(More)