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Brain-derived neurotrophic factor (BDNF) and other neurotrophins are believed to play an important role in affective disorders. In this study we investigated plasma-BDNF response during an incremental exercise test in 18 patients suffering from moderate major depressive disorder (MDD) and 18 controls. The patients were not treated with antidepressants or(More)
OBJECTIVE This study was undertaken to assess mortality, complications and major morbidity during the first 30 days after lung cancer surgery and to estimate the significance of presurgical risk factors. METHODS The study was based on all patients referred for surgery for primary lung cancer from 1 January 1987 to 1 September 1999. There were in total 616(More)
BACKGROUND Surgical resection is currently standard treatment in early stage lung cancer. The aim of the present study was to identify stage-related factors and patient characteristics influencing survival after complete resection. METHODS We identified 395 patients with non-small cell lung cancer who had undergone potentially radical operation during(More)
Two groups of rats were subjected to segmental ischaemia of the small intestine for 2 h. According to our previous findings such ischaemia causes impairment of the central circulation as well as of the splanchnic blood flow. Dopamine treatment was initiated 30 or 90 min after the establishment of ischaemia. In the 30-min group cardiac output increased and(More)
Two groups of rats were subjected to a segmental intestinal ischaemia of a degree which, according to earlier investigations with this experimental model, causes secondary impairment of the splanchnic blood flow. Both groups were given plasma and an alpha-adrenergic blocking agent (phenoxybenzamine). They were also given dopamine but in different doses, 12(More)
The influence of dopamine blocking agents, namely pimozide 0.1 mg X kg-1 body weight (b.w.) and metoclopramide 3 mg X kg-1 b.w., on the effects of dopamine on central and regional haemodynamics was studied in rats. The metoclopramide dose was given twice during the experiments. An experimental model involving segmental ischaemia of the small intestine was(More)
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