Gunja Gupta

Learn More
Solid tumors are dependent on preexisting vasculature and neovascularization for their growth. Successful cancer therapies targeting the tumor vasculature would be expected to block the existing tumor blood supply and to prevent tumor neovascularization. We tested the antitumor activity of experimental therapy with 2 distinct antiangiogenic drugs.(More)
Recombinant proteins can be targeted to the Escherichia coli periplasm by fusing them to signal peptides. The popular pET vectors facilitate fusion of target proteins to the PelB signal. A systematic comparison of the PelB signal with native E. coli signal peptides for recombinant protein expression and periplasmic localization is not reported. We chose the(More)
Objective Eukaryotic cilia/flagella are dynamic microtubule (MT)-based organelles. The ciliary axoneme is built from a radial scaffold of 9 MT doublets, plus a central MT pair, in the case of motile cilia. The axoneme is templated by a basal body (BB)/centriole derived from the mother centriole, in the case of animal cells, which presents sub-distal and(More)
  • 1