Gunilla Westergren

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Fresh isolates of Streptococcus mutans, Streptococcus sanguis, and Streptococcus salivarius from human dental plaque were all highly hydrophobic. After repeated subculture in vitro on blood agar, strains of S. mutans serotype c showed decreased hydrophobicity, whereas serotype d/g strains did not. Parallel to the decreased hydrophobicity in the serotype c(More)
A micromethod was developed for quantitative estimation in saliva of Streptococcus mutans and lactobacilli. With a semiautomatic pipette, 25 microliter of diluted saliva was spotted on the surface of an agar plate containing a selective medium. This volume gave a spot with a diameter of about 10 mm in which separate colonies could be counted. The results(More)
This paper describes the effects of the thiol compounds glutathione and N-acetylcysteine and the seleno-organic agent Ebselen on the development of Sephadex-induced lung edema and cell infiltration in the rat. Neither thiol had any effect upon the development of the edema when administered in large, repeated doses. In contrast, when Ebselen was(More)
Three chlorhexidine-sensitive strains of Streptococcus sanguis developed resistance to chlorhexidine when grown as continuous cultures in a fermenter containing medium with increasing concentrations of the drug. The MIC of the test strains increased by between two and three dilution steps and these high values were maintained after daily transfer in(More)
Metoprolol is a relatively beta 1-selective beta-blocker used extensively to treat hypertension and angina and as a prophylaxis after myocardial infarction. Conventional formulations are usually administered twice daily and the drug has a tendency to lose its selectivity of action at higher plasma concentrations. Two controlled release formulations,(More)
The effect of chlorhexidine on the proportions of Streptococcus mutans and Streptococcus sanguis in plaque was studied in hamsters fed a diet containing 28% sucrose. In animals given chlorhexidine in their drinking water for 10 d a decrease in the population of S. mutans and an increase of S. sanguis occurred in the plaque. Following the removal of(More)
Indium-113m (t1/2 = 100 min; gamma-emission of 393 keV) in trace amounts was injected i.v. in rats. Blood was collected by heart puncture 15 min after the injection, and blood plasma was separated by centrifugation. Gel filtration of plasma on Sephadex G-25M equilibrated with glycine/HCl (pH 2.2-3.6), NaHCO3/CO2 (pH 4.0-11.0) glycine/NaOH (pH 8.6-10.6) or(More)
The distribution of systematically injected In-113m (t1/2 = 100 min) in organs of the rat was analyzed, and the use of the isotope for in vivo and in vitro gamma-radiation detection studies of blood plasma protein extravasation was demonstrated in skin, muscle, and tumor. In-113m was slowly excreted from rats. One to 6 h after injection the blood held 3%(More)
Transformant strains of streptomycin-resistant Streptococcus sanguis persisted 2.5 years after oral implantation in 6 out of 11 subjects. Natural transmission of these bacteria to spouses had occurred in 5 of the 6 infected subjects. At follow-up examinations, the median value of streptomycin-resistant Strep. sanguis per ml saliva was 226,000 c.f.u. in the(More)