Upregulation of miRNA3195 and miRNA374b Mediates the Anti-Angiogenic Properties of Melatonin in Hypoxic PC-3 Prostate Cancer Cells
The findings suggest that upregulation of miRNA3195 and miRNA374b mediates anti-angiogenic property induced by melatonin in hypoxic PC-3 cells.
Blockage of epithelial to mesenchymal transition and upregulation of let 7b are critically involved in ursolic acid induced apoptosis in malignant mesothelioma cell
- E. Sohn, Gunho Won, Sung-Hoon Kim
- Biology, MedicineInternational Journal on Biological Sciences
- 18 October 2016
The findings suggest that ursolic acid induces apoptosis via inhibition of EMT and activation of let7b in mesothelioma cells as a potent chemotherapeutic agent for treatment of malignant mesoteliomas.
Inhibitory effect of ethanol extract of Ocimum sanctum on osteopontin mediated metastasis of NCI-H460 non-small cell lung cancer cells
- Tae-kyung Kwak, E. Sohn, Sung-Hoon Kim
- Biology, MedicineBMC Complementary and Alternative Medicine
- 27 October 2014
The findings suggest that anti-metastatic mechanism of EEOS is mediated by inhibition of PI3K/Akt in OPN treated NCI-H460 non-small cell lung cancer cells.
mTOR-Dependent Role of Sestrin2 in Regulating Tumor Progression of Human Endometrial Cancer
Upregulation of SESN2 statistically correlated with shorter overall survival and disease-free survival in patients with endometrial cancer, and a relationship between S ESN2, the mTORC1 pathway, and endometri cancer growth, suggesting SESn2 as a potential therapeutic target in endometrian cancer.
CCR4-NOT2 Promotes the Differentiation and Lipogenesis of 3T3-L1 Adipocytes via Upregulation of PPARγ, CEBPα and Inhibition of P-GSK3α/β and β-Catenin
It is demonstrated that CNOT2 promotes the differentiation of 3T3-L1 preadipocytes via upregulation of PPARγ, and CEBPα and inhibition of GSK3α/β and β-catenin signaling as a potent molecular target for obesity.
Regulation of crosstalk between epithelial to mesenchymal transition molecules and MMP-9 mediates the antimetastatic activity of anethole in DU145 prostate cancer cells.
The present findings suggest that anethole exerts antimetastatic activity via regulation of crosstalk between EMT molecules and MMP-9 on the basis of the in vitro data obtained.
Generation of ROS by Decursin selectively induces the ER stress pathway components ATF4/PERK leading to the synergistic enhancement of TRAIL‐induced apoptosis
Upregulation of microRNA135a-3p and death receptor 5 plays a critical role in Tanshinone I sensitized prostate cancer cells to TRAIL induced apoptosis
The findings suggest that Tanshinone I enhances TRAIL mediated apoptosis via upregulation of miR135a-3p mediated DR5 in prostate cancer cells as a potent TRAIL sensitizer.
Activation of JNK and IRE1 is critically involved in tanshinone I-induced p62 dependent autophagy in malignant pleural mesothelioma cells: implication of p62 UBA domain
Findings demonstrate that Tan I exerts antitumor activity through a compromise between apoptosis and p62/SQSTM1-dependent autophagy via activation of JNK and IRE 1 in malignant mesothelioma cells.
Decursin enhances TRAIL‐induced apoptosis through oxidative stress mediated‐ endoplasmic reticulum stress signalling in non‐small cell lung cancers
- Jaekwang Kim, Miyong Yun, Sung-Hoon Kim
- Biology, ChemistryBritish Journal of Pharmacology
- 1 March 2016
The TNF‐related apoptosis‐inducing ligand (TRAIL) is a promising anticancer agent due to its remarkable ability to selectively kill tumour cells. However, because most tumours exhibit resistance to…