Guneet Walia

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INTRODUCTION The Prouts Neck Meetings on Prostate Cancer began in 1985 through the efforts of the Organ Systems Branch of the National Cancer Institute to stimulate new research and focused around specific questions in prostate tumorigenesis and therapy. METHODS These meetings were think tanks, composed of around 75 individuals, and divided equally(More)
Dephosphocoenzyme A kinase performs the transfer of the γ-phosphate of ATP to dephosphocoenzyme A, catalyzing the last step of coenzyme A biosynthesis. This enzyme belongs to the P-loop-containing NTP hydrolase superfamily, all members of which posses a three domain topology consisting of a CoA domain that binds the acceptor substrate, the nucleotide(More)
Prostate Cancer Foundation (PCF) convened its 19th Annual Scientific Retreat October 25-27, 2012, in Carlsbad, CA. Each year, this event brings together diverse researchers in a collaborative forum to present and discuss new and largely unpublished findings for prostate cancer diagnosis, prognosis, and treatment and defines the challenges to ending this(More)
T here is a lot to learn from transnational research collaboration, and the Prostate Cancer Foundation (PCF) is dedicated to building bridges around the world to address complex scientific and clinical issues related to the development of improved diagnostics and therapeutics for metastatic prostate cancer. With the goal of improving patient care for men(More)
BACKGROUND Targeting the biosynthetic pathway of Coenzyme A (CoA) for drug development will compromise multiple cellular functions of the tubercular pathogen simultaneously. Structural divergence in the organization of the penultimate and final enzymes of CoA biosynthesis in the host and pathogen and the differences in their regulation mark out the final(More)
Being vastly different from the human counterpart, we suggest that the last enzyme of the Mycobacterium tuberculosis Coenzyme A biosynthetic pathway, dephosphocoenzyme A kinase (CoaE) could be a good anti-tubercular target. Here we describe detailed investigations into the regulatory features of the enzyme, affected via two mechanisms. Enzymatic activity is(More)
n engl j med 376;21 May 25, 2017 mary care practices for this demonstration, which qualifies as an Alternative Payment Model under the Medicare Access and CHIP Reauthorization Act (MACRA). Calls for fundamental payment and EHR reform are likely to trigger considerable discomfort and resistance. Many practice managers and payers and some clinician(More)
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