Gun Jörneskog

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OBJECTIVE Chronic foot ulcers are a common, severe, and expensive complication threatening life and limb in patients with diabetes. The aim of the present study was to investigate the effect of dalteparin on ulcer outcome in patients with diabetes, peripheral arterial occlusive disease, and chronic foot ulcers. RESEARCH DESIGN AND METHODS A total of 87(More)
T he pathogenesis behind diabetic mi-croangiopathy is complex; both genetic (1–3) and metabolic factors (4 – 6) are clearly of importance. Recently, it has been demonstrated that not only patients with diabetes but also healthy individuals at risk for diabetes have functional vascular disturbances (7). These findings suggest that factors other than(More)
BACKGROUND Diabetes and impaired glucose tolerance (IGT) are major risk factors for atherosclerosis including coronary artery disease (CAD). The present study's aim was to investigate the importance of glucose tolerance for long-term clinical outcome in patients with acute coronary syndrome (ACS). METHODS A total 1062 consecutive patients, 781 men and 281(More)
E ndothelin (ET)-1 levels are increased in patients with type 2 diabetes and may contribute to vascular complications and insulin resistance. Recently, we showed that ET A receptor blockade improves nutritive skin capillary circulation in patients with type 2 diabetes and microangiopathy (1). In this study, we investigated the effect of ET A receptor(More)
Fifty-four type 2 diabetic patients with neuroischemic foot ulcers were randomised to treatment with 5000 IU of dalteparin, (n = 28), or physiological saline, (n = 26), once daily until ulcer healing or for a maximum of 6 months. Thirty-three patients had normo-, 15 micro-, and 6 macroalbuminuria. The urinary levels of IgM and IgG(2) were elevated in 47 and(More)
OBJECTIVE Patients with type 1 diabetes form a less permeable fibrin network, which could contribute to their increased risk of cardiovascular disease (CVD). Low-dose aspirin treatment is the standard in the management of CVD; however, the effect seems reduced in patients with diabetes. We investigated the effects of low- and high-dose aspirin treatment on(More)
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