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OBJECTIVE The present study was undertaken to compare the predictive values of transcutaneous oxygen tension (TcPO2) and toe blood pressure (TBP) measurements for ulcer healing in patients with diabetes and chronic foot ulcers. RESEARCH DESIGN AND METHODS Investigated prospectively were 50 diabetic patients (37 men) with chronic foot ulcers. The age was(More)
The relation between high on-treatment platelet reactivity (HPR), and the level of glucose intolerance and insulin resistance (IR) was studied in clopidogrel-treated patients with minor ischemic stroke or TIA. The cohort consisted of 66 patients, 11 of which had known type 2 diabetes mellitus (DM). Platelet aggregation in whole blood (Multiplate™) and(More)
BACKGROUND The cause of diabetic foot ulcers is multifactorial, e.g., neuropathy and angiopathy, leading to functional disturbances in the macrocirculation and skin microcirculation. Adequate tissue oxygen tension is an essential factor in infection control and wound healing. Hyperbaric oxygen (HBO) therapy, daily sessions of oxygen breathing at 2.5-bar(More)
BACKGROUND High glucose levels are associated with increased morbidity and mortality after coronary surgery and in intensive care. The influence of perioperative hyperglycaemia on the outcome after infrainguinal bypass surgery among diabetic patients is largely unknown. The aim was to determine whether high perioperative glucose levels were associated with(More)
OBJECTIVE Chronic foot ulcers are a common, severe, and expensive complication threatening life and limb in patients with diabetes. The aim of the present study was to investigate the effect of dalteparin on ulcer outcome in patients with diabetes, peripheral arterial occlusive disease, and chronic foot ulcers. RESEARCH DESIGN AND METHODS A total of 87(More)
T he pathogenesis behind diabetic mi-croangiopathy is complex; both genetic (1–3) and metabolic factors (4 – 6) are clearly of importance. Recently, it has been demonstrated that not only patients with diabetes but also healthy individuals at risk for diabetes have functional vascular disturbances (7). These findings suggest that factors other than(More)
Ten diabetic patients with peripheral arterial occlusive disease, peripheral polyneuropathy and chronic foot ulcers were given 2500 U low molecular weight heparin (Fragmin, Kabi-Pharmacia AB, Sweden) subcutaneously once a day during 8 weeks. The mean age was 63 (47-80) years and the mean duration of foot ulcers 8 (4-12) months. All patients had previously(More)
BACKGROUND Preterm birth is a risk factor for blood pressure (BP) elevation already at young age. The mechanisms are unknown. Low skin capillary density and impaired endothelial function characterize adults with hypertension. OBJECTIVES To investigate the early relationships between BP, capillary density and endothelial function after very preterm birth.(More)
We investigated the effects of statin treatment on platelet-derived microparticles (PMPs) and thrombin generation in atherothrombotic disease. Nineteen patients with peripheral arterial occlusive disease were randomised to eight weeks of treatment with atorvastatin or placebo in a cross-over fashion. Expression of GPIIIa (CD61), P-selectin (CD62P), tissue(More)
The aim of the present study was to investigate if diabetes negatively influences the skin microvascular reactivity in the toes of patients with peripheral vascular disease (PVD). Twenty healthy subjects, 20 diabetic, and 20 non-diabetic patients with PVD participated. One foot in each subject was investigated. The patient groups were matched for age, sex,(More)