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Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH
Significance We identified a human-specific endogenous retroviral insert (hsERV) that acts as an enhancer for human PRODH, hsERV_PRODH. PRODH encodes proline dehydrogenase, which is involved inExpand
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Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity
Semax (100 µM) and its Pro-Gly-Pro fragment (20 and 100 µM) delayed the development of calcium dysregulation and reduction of the mitochondrial potential in cultured cerebellar granule cells underExpand
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NGF but not BDNF overexpression protects hippocampal LTP from beta-amyloid-induced impairment
Two major neurotrophic factors, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are involved in a number of physiological processes associated with neuronal growth, survivalExpand
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Transient disturbances in contextual fear memory induced by Aβ(25–35) in rats are accompanied by cholinergic dysfunction
Damage to the medial septum (MS) or disruption of the septo-hippocampal pathway is often considered as a basis for memory impairments, manifesting in the hippocampus-dependent behavioral paradigms.Expand
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Changes in mitochondrial NAD(P)H and glutamate-induced delayed calcium deregulation in cultured rat cerebellar granule neurons
Changes in cytosolic [Ca2+]i, mitochondrial potential (ΔVm), and mitochondrial NAD(P)H autofluorescence were compared in experiments on cultured cerebellar granule cells co-loaded with Ca2+ indicatorExpand
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Na+/Ca2+ exchange and regulation of cytoplasmic concentration of calcium in rat cerebellar neurons treated with glutamate
In the present work, the forward and/or reversed Na+/Ca2+ exchange in cerebellar granular cells was suppressed by substitution of Na0+ by Li+ before, during, and after exposure to glutamate forExpand
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Optimization of a preparation of lentiviral particles for transduction of neurons in vivo
The transduction of neurons using the lentiviral systems is a widely used method for the delivery of genetic material to cells of the nervous system in vivo. In the present study, we optimized theExpand
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The expression of the TrkA and TrkB high-affinity neurotrophin receptors in the rat hippocampus after intracerebroventricular administration of Aβ(25–35)
We studied the changes in the expression of high-affinity TrkA and TrkB receptors of the nerve-growth factor and brain-derived neurotrophic factor in the rat hippocampus at different time pointsExpand
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The Expression of the TrkA
We studied the changes in the expression of high affinity TrkA and TrkB receptors of the nerve growth factor and brain derived neurotrophic factor in the rat hippocampus at different time pointsExpand