Guldal Yılmaz

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BACKGROUND The current study is the first to evaluate the biochemical and histopathological features of hepatic toxicity of lapatinib. METHODS Twenty Wistar albino rats were allocated into three groups: experimental toxicity was induced with lapatinib (10mg/kg) administered for 28 days (Group 1), 42 days (Group 2) orally in a single dose by gavage.(More)
BACKGROUND We aimed to investigate serum Pin1 as an indicator of the presence of nonalcoholic steatohepatitis (NASH) and its association with the histopathological liver fibrosis stages. METHODS Serum samples were collected from consecutive biopsy-proven NASH patients and healthy controls, and then serum levels of Pin1 were measured. The correlations(More)
BACKGROUND We aimed to evaluate the hepatic immunoreactivity of angiotensin-converting enzyme 2 (ACE2) in non-alcoholic steatohepatitis (NASH) patients, elucidate its association with the clinicopathological characteristics and also determine its role in fibrosis progression. METHODS The consecutive biopsy proven NASH patients were subdivided into two(More)
We proposed to evaluate the association between serum indirect bilirubin levels and liver fibrosis in patients with chronic hepatitis C (CHC) genotype 1b. Biopsy proven CHC genotype 1b patients' demographics, clinical and histopathological characteristics were evaluated. Logistic regression analysis was done to evaluate the clinical, laboratory and(More)
BACKGROUND Hepatic damage due to chronic hepatitis C virus (HCV) genotype 1b infection varies widely. OBJECTIVES We aimed to investigate whether estrogen receptor alpha (ERα) plays a role in liver fibrosis in patients infected with HCV genotype 1b. PATIENTS AND METHODS All the consecutive patients who received the same standard treatment protocol for(More)
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