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Twelve 1-N-substituted thiocarbamoyl-3-phenyl-5-thienyl-2-pyrazoline derivatives were synthesized and their biological interactions with human plasma and erythrocyte acetylcholinesterase (AChE) and butrylcholinesterase (BuChE) enzymes were assessed. Compounds 3i-3l of newly synthesized N-substituted pyrazolines, which were presented as selective and(More)
The purpose of this study was to investigate the influence of clozapine on plasma serotonin, platelet serotonin and monoamine oxidase (MAO) levels in schizophrenic patients and to compare their results with those of unmedicated healthy controls. Groups of 20 outpatients with schizophrenia and 20 healthy controls matched for age, sex and smoking status were(More)
The inhibitory effects of flavonoids on monoamine oxidases (MAOs) have attracted great interest since alterations in monoaminergic transmission are reported to be related to neurodegenerative diseases such as Parkinson's and Alzheimer's diseases and psychiatric disorders such as depression and anxiety, thus MAOs may be considered as targets for the(More)
  • Sıçan Akciğerinden, Saflaştırılan Semikarbazid, Duyarlı Amin Oksidaz, Enziminin Substrat Özgüllüğü, Samiye Yabanoglu, Gulberk Ucar
  • 2008
Objectives: The aim of this study was to investigate the substrate specificity of purified rat lung semicarbazide-sensitive amine oxidase. Methods: Substrate specificity and kinetics of purified rat lung semicarbazide sensitive amine oxidase were studied using benzylamine and methylamine as sub-strates. Substrate competition studies were also performed.(More)
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